APPBP2 and CNTFR

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		APPBP2	CNTFR
Gene Name		amyloid beta precursor protein (cytoplasmic tail) binding protein 2	ciliary neurotrophic factor receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane	Extrinsic Component Of Membrane Anchored Component Of Membrane Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex
	Molecular Function	Microtubule Motor Activity Protein Binding	Ciliary Neurotrophic Factor Receptor Activity Receptor Binding Cytokine Binding
	Biological Process	Intracellular Protein Transport Metabolic Process Intracellular Transport	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		79 interactors: AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 DCD DHRS2 DPEP1 EID3 EPT1 ERO1L FAM19A4 FAM92A1 FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 HIPK4 HIST1H2AK HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MGC34796 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747	9 interactors: APPBP2 CLCF1 CNTF CRLF1 HN1L IL6ST KRTAP4-12 LIFR PLSCR1
Entrez ID		10513	1271
HPRD ID		05616	00348
Ensembl ID		ENSG00000062725	ENSG00000122756
Uniprot IDs		Q92624	P26992
PDB IDs			1UC6
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Host Response To Stress Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Homocysteine Metabolic Process Cellular Response To Organic Substance	Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Response To Cytokine Positive Regulation Of Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Astrocyte Differentiation Cytokine-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Proliferation Negative Regulation Of Neuron Death Positive Regulation Of Protein Phosphorylation Regulation Of Astrocyte Differentiation Regulation Of Neuron Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Glial Cell Differentiation Regulation Of Neuron Death Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Positive Regulation Of Gliogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Signal Transduction Regulation Of Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Interleukin-11-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Gliogenesis Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Death Interleukin-27-mediated Signaling Pathway
Tagcloud ?		10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4	acidic afgf albino bfgf ciliary college dystrophy fgf fgfr1 fibrillary gfap hybridizations igfr inherited injured minimize neurotrophic persisted photoreceptor prompt rcs retina royal slower subretinal surgeons trkb vicinity
Tagcloud (Difference) ?		10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4	acidic afgf albino bfgf ciliary college dystrophy fgf fgfr1 fibrillary gfap hybridizations igfr inherited injured minimize neurotrophic persisted photoreceptor prompt rcs retina royal slower subretinal surgeons trkb vicinity
Tagcloud (Intersection) ?