APPBP2 and RRS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		APPBP2	RRS1
Description		amyloid beta precursor protein binding protein 2	regulator of ribosome synthesis 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Preribosome, Large Subunit Precursor
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Binding Protein Binding 5S RRNA Binding
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Ribosomal Large Subunit Assembly Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Hematopoietic Progenitor Cell Differentiation Mitotic Metaphase Chromosome Alignment Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Nucleolus
Pathways
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	5 interacting genes: APPBP2 CFTR FXYD2 OGT SDCBP
Entrez ID		10513	23212
HPRD ID		05616	15277
Ensembl ID		ENSG00000062725	ENSG00000179041
Uniprot IDs		Q92624	Q15050
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV	8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FL0 8IR1 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Protein Binding	Intracellular Chemical Homeostasis Positive Regulation Of Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Interleukin-5 Receptor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cellular Homeostasis Positive Regulation Of Transport Chemical Homeostasis Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Exocytosis Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Interleukin-5 Receptor Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Protein O-acetylglucosaminyltransferase Activity Hyperosmotic Salinity Response Ion Channel Regulator Activity Cellular Hyperosmotic Salinity Response Basolateral Plasma Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Extracellular Exosome Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Sodium Ion Export Across Plasma Membrane Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Salt Stress Amelogenesis Positive Regulation Of Secretion By Cell ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Substrate-dependent Cell Migration, Cell Extension Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription By Glucose Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
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