APPBP2 and AIM2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		APPBP2	AIM2
Description		amyloid beta precursor protein binding protein 2	absent in melanoma 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Site Of Double-strand Break Canonical Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Double-stranded DNA Binding Protein Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Inflammatory Response Immune Response DNA Damage Response Brain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta T Cell Homeostasis Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Maturation Defense Response To Virus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Cellular Homeostasis Pyroptotic Inflammatory Response Cellular Response To Cytokine Stimulus Cellular Response To Xenobiotic Stimulus AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Pyroptosome Complex Assembly
Pathways			Cytosolic sensors of pathogen-associated DNA The AIM2 inflammasome The AIM2 inflammasome
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)	Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Psoriasis ( 25854761)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	4 interacting genes: ANP32B APPBP2 RNF4 SQSTM1
Entrez ID		10513	9447
HPRD ID		05616	05202
Ensembl ID		ENSG00000062725	ENSG00000163568
Uniprot IDs		Q92624	O14862
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV	3RN2 3RN5 3VD8 4O7Q 6MB2 7K3R
Enriched GO Terms of Interacting Partners?		Protein Binding	Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination PML Body Post-translational Protein Modification Brown Fat Cell Proliferation Amphisome Regulation Of Protein Localization Regulation Of Kinetochore Assembly Macromolecule Catabolic Process Regulation Of Centromere Complex Assembly SUMO Polymer Binding Negative Regulation Of Protein Localization To Chromatin Microtubule End Proteolysis Lewy Body Response To Mitochondrial Depolarisation Protein Polyubiquitination Intracellular Membraneless Organelle Fat Cell Proliferation Protein Localization To Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Chromatin Ubiquitin-modified Protein Reader Activity Nucleoplasm Autolysosome Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Aggrephagy Negative Regulation Of Ferroptosis Protein Targeting To Vacuole Involved In Autophagy Regulation Of Ferroptosis Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Complex Stability Positive Regulation Of Protein Localization Molecular Sequestering Activity Pexophagy Proteasomal Protein Catabolic Process Inclusion Body Cul2-RING Ubiquitin Ligase Complex RNA Polymerase Binding Positive Regulation Of Protein Export From Nucleus Ventricular System Development Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Long-term Synaptic Potentiation Intracellular Protein Transport
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