APPBP2 and RNGTT

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		APPBP2	RNGTT
Name		amyloid beta precursor protein binding protein 2	RNA guanylyltransferase and 5'-phosphatase
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Catalytic Activity MRNA Guanylyltransferase Activity Polynucleotide 5'-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Binding ATP Binding GTP Binding RNA Guanylyltransferase Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Inorganic Triphosphate Phosphatase Activity MRNA 5'-triphosphate Monophosphatase Activity
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Nucleobase-containing Compound Metabolic Process 7-methylguanosine MRNA Capping RNA Processing MRNA Processing
Pathways		None	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE
GWAS		Interleukin-6 levels ( 33517400 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Waist-hip ratio ( 28552196 )	Colorectal or endometrial cancer ( 26621817 ) Depression in smokers ( 30219690 ) Graft survival time in renal transplantation (donor effect) ( 32080893 ) Height ( 31562340 ) Response to statin therapy ( 20339536 ) Simvastatin-induced myopathy ( 31220337 ) Subcutaneous adipose tissue ( 22589738 )
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	4 interacting genes: APPBP2 CEBPA CRYAA RNMT
Entrez ID		10513	8732
HPRD ID		05616	04621
Ensembl ID		ENSG00000062725	ENSG00000111880
Uniprot IDs		Q92624	B4DSJ8 O60942
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV	2C46 3S24 8P4A 8P4B 8P4C 8P4D 8P4E 8W8E 8W8F
GO Terms Enriched among Interactors		Protein Binding	Granulocyte Differentiation Mitochondrion Organization Lung Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission MRNA Capping Enzyme Complex MRNA 5'-cap (guanine-N7-)-methyltransferase Activity MRNA Cap Methyltransferase RNMT:RAMAC Complex RNA 5'-cap (guanine-N7)-methylation Myeloid Leukocyte Differentiation CHOP-C/EBP Complex Response To Phenylpropanoid White Fat Cell Proliferation Myeloid Cell Differentiation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Lens Fiber Cell Morphogenesis Cell Morphogenesis Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Regulation Of NK T Cell Differentiation 7-methylguanosine MRNA Capping RNA (guanine-N7)-methylation Fat Cell Proliferation Microvesicle Leukocyte Differentiation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding RNA Metabolic Process Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Animal Organ Development Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Anterograde Synaptic Vesicle Transport AP-3 Adaptor Complex