APPBP2 and TNP2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		APPBP2	TNP2
Name		amyloid beta precursor protein binding protein 2	transition protein 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Nucleosome Nucleus Chromosome Nucleolus
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Spermatogenesis Acrosome Reaction Penetration Of Zona Pellucida Positive Regulation Of Protein Processing Cell Differentiation Sperm DNA Condensation
GWAS		Interleukin-6 levels ( 33517400 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Waist-hip ratio ( 28552196 )	Asthma ( 31959851 ) Bulimia nervosa ( 23568457 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Multiple sclerosis ( 22190364 ) Type 1 diabetes ( 18978792 )
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	17 interacting genes: APPBP2 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 MDFI NOTCH2NLA PRKACA PRKACB PRKACG PRKCA
Entrez ID		10513	7142
HPRD ID		05616	01831
Ensembl ID		ENSG00000062725	ENSG00000178279
Uniprot IDs		Q92624	Q05952 Q4VB56
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV	Not available
GO Terms Enriched among Interactors		Protein Binding	Keratin Filament Intermediate Filament CAMP-dependent Protein Kinase Activity CAMP-dependent Protein Kinase Complex High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Multicellular Organismal-level Water Homeostasis Cellular Response To Fluid Shear Stress Renal System Process Ciliary Base Response To Fluid Shear Stress Cytosol Multicellular Organismal-level Chemical Homeostasis Protein Kinase A Regulatory Subunit Binding Protein Serine Kinase Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Smoothened Signaling Pathway Protein Kinase Activity Regulation Of Protein Processing Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Maturation Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Regulation Of Body Fluid Levels Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Smoothened Signaling Pathway TOR Signaling Positive Regulation Of Insulin Secretion Neural Tube Closure