PRKACB and ACVR1B

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PRKACB	ACVR1B
Name		protein kinase cAMP-activated catalytic subunit beta	activin A receptor type 1B
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Extracellular Exosome Ciliary Base	Plasma Membrane Cell Surface Membrane Receptor Complex Activin Receptor Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Activin Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding I-SMAD Binding
	Biological Process	Neural Tube Closure Renal Water Homeostasis Protein Phosphorylation Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Nutrient Levels High-density Lipoprotein Particle Assembly TORC1 Signaling Negative Regulation Of Smoothened Signaling Pathway Regulation Of Protein Processing Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of TORC1 Signaling	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Regulation Of Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 GPER1 signaling GPER1 signaling Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin
Drugs		Phosphonothreonine Fostamatinib	ATP Fostamatinib
GWAS		Breast cancer (male) ( 23001122 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Metabolite levels ( 23823483 )	Adenocarcinoma ( 26732429 ) Age-related hearing impairment ( 24939585 ) Granulocyte count ( 27863252 ) Hematocrit ( 29403010 ) Hemoglobin ( 29403010 ) Lung cancer ( 26732429 ) Neutrophil count ( 27863252 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Serum CC16 levels ( 32839289 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Urate levels ( 23263486 )
Interacting Genes		15 interacting genes: ACVR1B APPBP2 ARFGAP1 AVPI1 CSNK2A1 FBXO7 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2 TP73	22 interacting genes: ACVR2B BAG6 BAMBI BMPR2 CRIPTO FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TGFBRAP1
Entrez ID		5567	91
HPRD ID		01482	03193
Ensembl ID		ENSG00000142875	ENSG00000135503
Uniprot IDs		A0A087WVC4 B1APF9 B1APG3 B2RB89 B7ZA00 P22694	P36896
PDB IDs		Not available	7MRZ 7OLY
GO Terms Enriched among Interactors		CAMP-dependent Protein Kinase Inhibitor Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Negative Regulation Of Growth Hair Follicle Development Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Negative Regulation Of CAMP-dependent Protein Kinase Activity Protein Kinase Inhibitor Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Protein Processing Sperm DNA Condensation Sperm DNA Decondensation Positive Regulation Of Protein Maturation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Developmental Process Regulation Of Protein Processing	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Activin Receptor Signaling Pathway Regulation Of SMAD Protein Signal Transduction Activin Receptor Binding SMAD Protein Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Cell Surface Receptor Signaling Pathway Anterior/posterior Pattern Specification Regulation Of Primary Metabolic Process Heteromeric SMAD Protein Complex Anatomical Structure Morphogenesis Lung Development Positive Regulation Of SMAD Protein Signal Transduction Type I Transforming Growth Factor Beta Receptor Binding Mesoderm Formation Nodal Signaling Pathway Gastrulation Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Embryonic Pattern Specification Formation Of Primary Germ Layer Gastrulation With Mouth Forming Second Regionalization Positive Regulation Of Ovulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Growth Factor Activity Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Axis Specification Roof Of Mouth Development Regulation Of Metabolic Process Response To Growth Factor Activin Receptor Activity, Type II Negative Regulation Of Follicle-stimulating Hormone Secretion Activin Responsive Factor Complex Cell Differentiation