PRKACB and TNP2

Number of citations: 0 (PubMedID 9837753)
Data Source: BioGRID (enzymatic study)

		PRKACB	TNP2
Name		protein kinase cAMP-activated catalytic subunit beta	transition protein 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Extracellular Exosome Ciliary Base	Nucleosome Nucleus Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Protein Serine Kinase Activity	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Renal Water Homeostasis Protein Phosphorylation Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Nutrient Levels High-density Lipoprotein Particle Assembly TORC1 Signaling Negative Regulation Of Smoothened Signaling Pathway Regulation Of Protein Processing Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of TORC1 Signaling	Spermatogenesis Acrosome Reaction Penetration Of Zona Pellucida Positive Regulation Of Protein Processing Cell Differentiation Sperm DNA Condensation
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 GPER1 signaling GPER1 signaling Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	None
Drugs		Phosphonothreonine Fostamatinib	None
GWAS		Breast cancer (male) ( 23001122 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Metabolite levels ( 23823483 )	Asthma ( 31959851 ) Bulimia nervosa ( 23568457 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Multiple sclerosis ( 22190364 ) Type 1 diabetes ( 18978792 )
Interacting Genes		15 interacting genes: ACVR1B APPBP2 ARFGAP1 AVPI1 CSNK2A1 FBXO7 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2 TP73	17 interacting genes: APPBP2 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 MDFI NOTCH2NLA PRKACA PRKACB PRKACG PRKCA
Entrez ID		5567	7142
HPRD ID		01482	01831
Ensembl ID		ENSG00000142875	ENSG00000178279
Uniprot IDs		A0A087WVC4 B1APF9 B1APG3 B2RB89 B7ZA00 P22694	Q05952 Q4VB56
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		CAMP-dependent Protein Kinase Inhibitor Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Negative Regulation Of Growth Hair Follicle Development Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Negative Regulation Of CAMP-dependent Protein Kinase Activity Protein Kinase Inhibitor Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Protein Processing Sperm DNA Condensation Sperm DNA Decondensation Positive Regulation Of Protein Maturation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Developmental Process Regulation Of Protein Processing	Keratin Filament Intermediate Filament CAMP-dependent Protein Kinase Activity CAMP-dependent Protein Kinase Complex High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Multicellular Organismal-level Water Homeostasis Cellular Response To Fluid Shear Stress Renal System Process Ciliary Base Response To Fluid Shear Stress Cytosol Multicellular Organismal-level Chemical Homeostasis Protein Kinase A Regulatory Subunit Binding Protein Serine Kinase Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Smoothened Signaling Pathway Protein Kinase Activity Regulation Of Protein Processing Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Maturation Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Regulation Of Body Fluid Levels Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Smoothened Signaling Pathway TOR Signaling Positive Regulation Of Insulin Secretion Neural Tube Closure