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PRKACB
Gene Name
protein kinase, cAMP-dependent, catalytic, beta
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Centrosome
Cytosol
Plasma Membrane
CAMP-dependent Protein Kinase Complex
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Ciliary Base
Molecular Function
Magnesium Ion Binding
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Biological Process
Neural Tube Closure
Renal Water Homeostasis
Carbohydrate Metabolic Process
Glucose Metabolic Process
Gluconeogenesis
Energy Reserve Metabolic Process
Protein Phosphorylation
Water Transport
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Synaptic Transmission
Blood Coagulation
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Triglyceride Catabolic Process
Activation Of Protein Kinase A Activity
Intracellular Signal Transduction
Small Molecule Metabolic Process
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Insulin Secretion
Negative Regulation Of Meiotic Cell Cycle
Transmembrane Transport
Regulation Of Protein Processing
Cellular Response To Glucagon Stimulus
Response To Clozapine
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways
Signaling by GPCR
Ca-dependent events
CaM pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Metabolism of lipids and lipoproteins
Integration of energy metabolism
Hedgehog 'off' state
Phospholipase C-mediated cascade
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
PLCG1 events in ERBB2 signaling
Gluconeogenesis
Glucose metabolism
DAP12 signaling
Rap1 signalling
Myoclonic epilepsy of Lafora
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
Glycogen storage diseases
PKA-mediated phosphorylation of key metabolic factors
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Glucagon signaling in metabolic regulation
Signaling by PDGF
Calmodulin induced events
DAP12 interactions
PKA-mediated phosphorylation of CREB
Opioid Signalling
PKA activation
Aquaporin-mediated transport
Factors involved in megakaryocyte development and platelet production
CREB phosphorylation through the activation of Adenylate Cyclase
EGFR interacts with phospholipase C-gamma
Signaling by ERBB2
Signaling by EGFR
PKA-mediated phosphorylation of CREB
Signaling by VEGF
Downstream signal transduction
Calmodulin induced events
Signaling by EGFR in Cancer
PKA activation
Metabolism of carbohydrates
Transmission across Chemical Synapses
Adaptive Immune System
VEGFA-VEGFR2 Pathway
DAG and IP3 signaling
CaM pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Downstream signaling of activated FGFR
DARPP-32 events
Post NMDA receptor activation events
Innate Immune System
PKA activation in glucagon signalling
Signalling by NGF
PLC beta mediated events
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
Signaling by Ligand-Responsive EGFR Variants in Cancer
Lipid digestion, mobilization, and transport
NGF signalling via TRKA from the plasma membrane
G-protein mediated events
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
PLC-gamma1 signalling
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Breast cancer (male) (
23001122
)
Protein-protein Interactions
12 interactors:
ACVR1B
APPBP2
ARFGAP1
CSNK2A1
NGFR
PKIA
PKIB
RPL27A
RPS6
SPP1
TNP1
TNP2
Entrez ID
5567
HPRD ID
01482
Ensembl ID
ENSG00000142875
Uniprot IDs
B1APF9
B1APG3
B2RB89
B7ZA00
P22694
PDB IDs
Enriched GO Terms of Interacting Partners
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Negative Regulation Of CAMP-dependent Protein Kinase Activity
Regulation Of CAMP-dependent Protein Kinase Activity
Intracellular Protein Transport
Protein Complex Disassembly
Establishment Of Localization In Cell
Locomotion
Reproductive Process
Cellular Protein Localization
Developmental Process Involved In Reproduction
Regulation Of Protein Metabolic Process
Sperm Motility
Protein Transport
Negative Regulation Of Axonogenesis
Establishment Of Protein Localization
Movement Of Cell Or Subcellular Component
Multicellular Organismal Reproductive Process
Fertilization, Exchange Of Chromosomal Proteins
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Intracellular Transport
Cellular Localization
Multicellular Organism Reproduction
Regulation Of Cell Growth
Regulation Of Cell Cycle
Viral Transcription
Regulation Of Mitotic Cell Cycle
Hair Follicle Development
Male Pronucleus Assembly
Positive Regulation Of Trophoblast Cell Migration
Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Apoptotic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Hair Cycle Process
SRP-dependent Cotranslational Protein Targeting To Membrane
Cotranslational Protein Targeting To Membrane
Protein Targeting To ER
Negative Regulation Of Cell Morphogenesis Involved In Differentiation
Programmed Cell Death
Establishment Of Protein Localization To Endoplasmic Reticulum
Negative Regulation Of Cell Cycle
Hair Cycle
Reproduction
Cell Death
Death
Regulation Of Protein Phosphorylation
Negative Regulation Of Hair Follicle Development
Protein Localization
Negative Regulation Of Neuron Projection Development
Protein Localization To Endoplasmic Reticulum
Regulation Of Cellular Protein Metabolic Process
Single Fertilization
Tagcloud
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agouti
albinism
asip
atf1
delta25
dopachrome
edn1
edn3
ednrb
exoc2
exocyst
kitlg
ludwigshafen
mc1r
microphthalmia
oca2
oculocutaneous
pigmentation
prkar1a
prkar2a
proopiomelanocortin
slc24a4
slc45a2
tautomerase
tpcn2
tubb3
tyrp1