APPBP2 and FXYD7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		APPBP2	FXYD7
Description		amyloid beta precursor protein binding protein 2	FXYD domain containing ion transport regulator 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Plasma Membrane Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Sodium Channel Regulator Activity ATPase Binding Ion Channel Regulator Activity
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	5 interacting genes: APOE APPBP2 ATP1A1 ATP1B1 SGTA
Entrez ID		10513	53822
HPRD ID		05616	09457
Ensembl ID		ENSG00000062725	ENSG00000221946
Uniprot IDs		Q92624	P58549
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Protein Binding	Extracellular Vesicle P-type Sodium:potassium-exchanging Transporter Activity Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Sodium:potassium-exchanging ATPase Complex Sodium Ion Export Across Plasma Membrane Membrane Repolarization During Action Potential Relaxation Of Muscle Cell Communication By Electrical Coupling Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication Involved In Cardiac Conduction Intracellular Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Cell Communication By Electrical Coupling Involved In Cardiac Conduction Intracellular Potassium Ion Homeostasis Negative Regulation Of Steroid Biosynthetic Process Membrane Repolarization Negative Regulation Of Steroid Metabolic Process Sodium Ion Homeostasis Potassium Ion Homeostasis Potassium Ion Import Across Plasma Membrane T-tubule Organelle Membrane Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Lipid Biosynthetic Process Export Across Plasma Membrane Establishment Of Protein Localization Lateral Plasma Membrane Regulation Of Sodium Ion Transport Negative Regulation Of Phospholipid Efflux Monoatomic Ion Homeostasis Localization Within Membrane Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Cellular Localization Monoatomic Cation Homeostasis Regulation Of Steroid Biosynthetic Process Intracellular Chemical Homeostasis Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Inorganic Cation Import Across Plasma Membrane Regulation Of System Process Regulation Of Striated Muscle Contraction Melanosome Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Sarcolemma
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