PRKACB and PKIA

Number of citations of the paper that reports this interaction (PMID 12798691)
3

Data Source:
HPRD (in vitro)

		PRKACB	PKIA
Gene Name		protein kinase, cAMP-dependent, catalytic, beta	protein kinase (cAMP-dependent, catalytic) inhibitor alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Ciliary Base	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Neural Tube Closure Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Negative Regulation Of Meiotic Cell Cycle Transmembrane Transport Regulation Of Protein Processing Cellular Response To Glucagon Stimulus Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Breast cancer (male) ( 23001122)	Bone mineral density ( 22504420) Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		12 interactors: ACVR1B APPBP2 ARFGAP1 CSNK2A1 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2	8 interactors: AGFG1 DYNLL1 EGFR JUNB PRKACA PRKACB PRKX XPO1
Entrez ID		5567	5569
HPRD ID		01482	05828
Ensembl ID		ENSG00000142875	ENSG00000171033
Uniprot IDs		B1APF9 B1APG3 B2RB89 B7ZA00 P22694	P61925
PDB IDs			1CMK 1JLU 1Q8T 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA 1YDR 2C1A 2C1B 2F7E 2GNI 2JDS 2JDT 2JDV 2L1L 2UVX 2UVY 2UVZ 2UW0 2UW3 2UW4 2UW5 2UW6 2UW7 2UW8 2VNW 2VNY 2VO0 2VO3 2VO6 2VO7 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AXA 4IAC 4IAD 4IAF 4IAI 4IAK 4IAY 4IAZ 4IE9 4IJ9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Intracellular Protein Transport Protein Complex Disassembly Establishment Of Localization In Cell Locomotion Reproductive Process Cellular Protein Localization Developmental Process Involved In Reproduction Regulation Of Protein Metabolic Process Sperm Motility Protein Transport Negative Regulation Of Axonogenesis Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Multicellular Organismal Reproductive Process Fertilization, Exchange Of Chromosomal Proteins Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Intracellular Transport Cellular Localization Multicellular Organism Reproduction Regulation Of Cell Growth Regulation Of Cell Cycle Viral Transcription Regulation Of Mitotic Cell Cycle Hair Follicle Development Male Pronucleus Assembly Positive Regulation Of Trophoblast Cell Migration Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Apoptotic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Hair Cycle Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Negative Regulation Of Cell Morphogenesis Involved In Differentiation Programmed Cell Death Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Cell Cycle Hair Cycle Reproduction Cell Death Death Regulation Of Protein Phosphorylation Negative Regulation Of Hair Follicle Development Protein Localization Negative Regulation Of Neuron Projection Development Protein Localization To Endoplasmic Reticulum Regulation Of Cellular Protein Metabolic Process Single Fertilization	Cellular Response To Growth Factor Stimulus Activation Of Phospholipase C Activity Response To Growth Factor Positive Regulation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Establishment Of Protein Localization Positive Regulation Of Phospholipase Activity Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Protein Localization Multicellular Organismal Reproductive Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organism Reproduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Tube Morphogenesis Regulation Of Intracellular Transport Regulation Of Cellular Localization Reproduction Anatomical Structure Formation Involved In Morphogenesis Activation Of Protein Kinase A Activity Morphogenesis Of An Epithelium Immune System Process Single Organism Reproductive Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Triglyceride Catabolic Process Cellular Response To Hormone Stimulus Reproductive Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Export From Nucleus Regulation Of Protein Transport Acylglycerol Catabolic Process Regulation Of Nucleocytoplasmic Transport Tissue Morphogenesis Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Renal Water Homeostasis Negative Regulation Of Embryonic Development Neurotrophin Signaling Pathway Tube Development Negative Regulation Of Smoothened Signaling Pathway Developmental Process Involved In Reproduction Positive Regulation Of Intracellular Transport Regulation Of Signal Transduction Mitotic Cell Cycle Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Phase Transition
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	acetaminophen alanine apap attenuation comparing corroborated determining differently discover dismutase exacerbation forty glutathione grouped hepatotoxicity peroxidase peroxynitrite pka potentiated pretreatment reflecting screen serious severity sought substantial superoxide susceptible transaminase
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	acetaminophen alanine apap attenuation comparing corroborated determining differently discover dismutase exacerbation forty glutathione grouped hepatotoxicity peroxidase peroxynitrite pka potentiated pretreatment reflecting screen serious severity sought substantial superoxide susceptible transaminase
Tagcloud (Intersection) ?