FLNC and XIRP1

Number of citations of the paper that reports this interaction (PubMedID 23115302)
55

Data Source:
BioGRID (pull down, two hybrid, far western blotting)

		FLNC	XIRP1
Description		filamin C	xin actin binding repeat containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Sarcoplasm Z Disc Sarcolemma Costamere Intercellular Bridge	Stress Fiber Adherens Junction Focal Adhesion Cell Junction Desmosome Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Identical Protein Binding Actin Filament Binding	RNA Binding Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Sarcomere Organization Muscle Cell Development	Actin Filament Organization Intracellular Protein Localization Myoblast Differentiation Involved In Skeletal Muscle Regeneration Satellite Cell Activation Involved In Skeletal Muscle Regeneration Actin Cytoskeleton Organization Negative Regulation Of Protein Binding
Pathways		Cell-extracellular matrix interactions
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	Apolipoprotein A1 levels ( 32203549) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Social communication problems ( 24564958)
Interacting Genes		35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	9 interacting genes: ACTA1 ENAH EVL FLNC NEB NEBL RNF10 SH3RF1 VASP
Entrez ID		2318	165904
HPRD ID		00018	16727
Ensembl ID		ENSG00000128591	ENSG00000168334
Uniprot IDs		Q14315 Q59H94	Q702N8
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX 7OUU 7OUV 7P0E 8PA0
Enriched GO Terms of Interacting Partners?		Z Disc Alpha1-adrenergic Receptor Activity Actin Binding Neuron-glial Cell Signaling Actin Filament-based Process FATZ Binding Heart Contraction Telethonin Binding Actin Cytoskeleton Organization Heart Process Adrenergic Receptor Activity Sarcomere Organization Cytoplasm Circulatory System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-actinin Binding Striated Muscle Tissue Development Muscle Structure Development Adrenergic Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Regulation Of System Process Muscle Tissue Development Anchoring Junction M Band Cytoskeleton Organization Dystroglycan Complex Supramolecular Fiber Organization Muscle Contraction Sarcoglycan Complex Actomyosin Structure Organization Regulation Of Intracellular Signal Transduction Structural Constituent Of Muscle System Process Regulation Of Signal Transduction Regulation Of Skeletal Muscle Tissue Regeneration Muscle Organ Development Regulation Of Supramolecular Fiber Organization Regulation Of Muscle System Process Muscle System Process Regulation Of Actin Filament Organization Regulation Of Protein Processing Actin Cytoskeleton Regulation Of Protein Maturation Cardiac Muscle Tissue Development Titin Binding Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cytoskeleton Regulation Of Cell Communication	Actin Filament Organization Actin Binding Profilin Binding Lamellipodium Supramolecular Fiber Organization Cardiac Muscle Thin Filament Assembly Actin Polymerization Or Depolymerization Filopodium Stress Fiber SH3 Domain Binding Cytoskeleton Z Disc Focal Adhesion Regulation Of Actin Filament Length Actin Filament Binding Neuron Projection Guidance Axon Guidance Structural Constituent Of Muscle Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Sarcomere Actin Cytoskeleton Protein Homotetramerization Cytoskeletal Protein Binding Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Protein Tetramerization Muscle Cell Development Cytoplasm Regulation Of Actin Filament Polymerization Neuron Projection Development Somatic Muscle Development Mesenchyme Migration Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Skeletal Muscle Thin Filament Assembly Cell Projection Negative Regulation Of Ruffle Assembly Actin Polymerization-dependent Cell Motility Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Schwann Cell Proliferation Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cytoskeleton Organization Striated Muscle Thin Filament Protein Homooligomerization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
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