FLNC and MYOZ3

Number of citations of the paper that reports this interaction (PubMedID 11842093)
0

Data Source:
HPRD (in vitro, in vivo)

		FLNC	MYOZ3
Description		filamin C	myozenin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Sarcoplasm Z Disc Sarcolemma Costamere Intercellular Bridge	Cytoplasm Actin Cytoskeleton Z Disc
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Identical Protein Binding Actin Filament Binding	Actin Binding Protein Binding Telethonin Binding FATZ Binding
	Biological Process	Actin Cytoskeleton Organization Sarcomere Organization Muscle Cell Development
Pathways		Cell-extracellular matrix interactions
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	71 interacting genes: ABI2 ACTN1 ACTN2 AKIRIN2 ASPG ATOSB ATXN1L BAG4 BCAS2 C10orf55 CCDC57 CIMIP2B CREM CRLF3 DAZAP2 DMRT3 EFS ENKD1 EXOC8 FAM168B FHL3 FHL5 FLNC GCM2 GOLGA6A GOLGA6L9 HSF2BP KANK2 KRT34 KRT36 KRT75 KRTAP19-5 KRTAP19-6 KRTAP6-1 KRTAP7-1 KRTAP8-1 KYNU LDB3 LENG8 LMO2 LMO3 LMO4 LONRF1 MAPK6 MORN3 MRPL38 MYO15B NEK6 NUTF2 PDLIM3 PITX1 PM20D2 PPP3CA PPP3CB PRDM6 PSMB4 PTK6 RINT1 RNF125 RUSC1 SPMIP5 TBX15 TCAP TEKT4 TRAPPC6A TSC1 TSSK3 UFSP1 YPEL3 ZNF620 ZNF688
Entrez ID		2318	91977
HPRD ID		00018	17624
Ensembl ID		ENSG00000128591	ENSG00000164591
Uniprot IDs		Q14315 Q59H94	Q8TDC0
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX 7OUU 7OUV 7P0E 8PA0
Enriched GO Terms of Interacting Partners?		Z Disc Alpha1-adrenergic Receptor Activity Actin Binding Neuron-glial Cell Signaling Actin Filament-based Process FATZ Binding Heart Contraction Telethonin Binding Actin Cytoskeleton Organization Heart Process Adrenergic Receptor Activity Sarcomere Organization Cytoplasm Circulatory System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-actinin Binding Striated Muscle Tissue Development Muscle Structure Development Adrenergic Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Regulation Of System Process Muscle Tissue Development Anchoring Junction M Band Cytoskeleton Organization Dystroglycan Complex Supramolecular Fiber Organization Muscle Contraction Sarcoglycan Complex Actomyosin Structure Organization Regulation Of Intracellular Signal Transduction Structural Constituent Of Muscle System Process Regulation Of Signal Transduction Regulation Of Skeletal Muscle Tissue Regeneration Muscle Organ Development Regulation Of Supramolecular Fiber Organization Regulation Of Muscle System Process Muscle System Process Regulation Of Actin Filament Organization Regulation Of Protein Processing Actin Cytoskeleton Regulation Of Protein Maturation Cardiac Muscle Tissue Development Titin Binding Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cytoskeleton Regulation Of Cell Communication	Z Disc Intermediate Filament Muscle Cell Development Cytoskeletal Protein Binding Cytoskeleton Organization Protein Binding Titin Z Domain Binding Sarcomere Organization Pseudopodium FATZ Binding Calmodulin-dependent Protein Phosphatase Activity Striated Muscle Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Organelle Organization Actin Filament Stress Fiber Cell Projection Protein Serine/threonine Phosphatase Complex
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