FLNC and ADRA1B

Number of citations of the paper that reports this interaction (PMID 15525470)
1

Data Source:
HPRD (two hybrid)

		FLNC	ADRA1B
Gene Name		filamin C, gamma	adrenoceptor alpha 1B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Actin Filament Binding	Alpha1-adrenergic Receptor Activity Protein Heterodimerization Activity
	Biological Process	Cell Junction Assembly Muscle Fiber Development	Blood Vessel Remodeling Response To Amphetamine Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Adult Heart Development Locomotory Behavior Cell Proliferation Visual Learning Cell Growth Regulation Of Vasoconstriction Organ Growth Intracellular Signal Transduction Glucose Homeostasis Response To Morphine Positive Regulation Of MAPK Cascade Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycogen Catabolic Process Behavioral Response To Cocaine Regulation Of Cardiac Muscle Contraction Adrenergic Receptor Signaling Pathway
Pathways		Cell junction organization Cell-extracellular matrix interactions	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Adrenoceptors G alpha (12/13) signalling events
Drugs			Midodrine Ziprasidone Dapiprazole Olanzapine Alfuzosin Clozapine Norepinephrine Phenylephrine Promazine Prazosin Chlorpromazine Doxazosin Labetalol Nicardipine Epinephrine Thioridazine Ergotamine Tamsulosin Methoxamine Trimipramine Risperidone Modafinil Propiomazine Doxepin Nefazodone Terazosin Pergolide Bromocriptine Quetiapine Aripiprazole Lisdexamfetamine Paliperidone Methotrimeprazine Dextroamphetamine Phendimetrazine Propericiazine Acepromazine Thioproperazine Dronedarone Sertindole Silodosin Droxidopa Xylometazoline
Diseases
GWAS
Protein-Protein Interactions		29 interactors: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 INPPL1 KCND2 KY MAP2K4 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	11 interactors: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1
Entrez ID		2318	147
HPRD ID		00018	00080
Ensembl ID		ENSG00000128591
Uniprot IDs		Q14315 Q59H94	P35368
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O
Enriched GO Terms of Interacting Partners?		Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Muscle Cell Development Blood Circulation Muscle Structure Development Heart Development Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Cardiovascular System Development Positive Regulation Of Systemic Arterial Blood Pressure Adrenergic Receptor Signaling Pathway Muscle Cell Differentiation Regulation Of Blood Pressure Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cardiac Muscle Tissue Development Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Organ Development Multicellular Organismal Development Developmental Process Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Muscle Organ Development Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Peptidyl-threonine Phosphorylation Striated Muscle Tissue Development Striated Muscle Cell Development System Development Muscle Tissue Development Regulation Of Heart Contraction Anatomical Structure Development Actin Cytoskeleton Organization Regulation Of The Force Of Heart Contraction By Chemical Signal Heart Contraction Actin Filament-based Process Myofibril Assembly Cell Development Regulation Of Blood Vessel Size Cellular Response To Carbohydrate Stimulus Regulation Of Tube Size Striated Muscle Cell Differentiation Adult Heart Development Muscle System Process Signaling Organ Growth Actomyosin Structure Organization Cell Communication Positive Regulation Of Heart Rate Peptidyl-serine Phosphorylation	Regulation Of The Force Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To External Stimulus Developmental Process Positive Regulation Of Phospholipase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Melanocyte Differentiation Negative Regulation Of Catalytic Activity Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Filopodium Assembly Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signal Transduction Regulation Of Muscle Contraction Regulation Of Developmental Pigmentation Regulation Of Heart Contraction Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Intracellular Signal Transduction Signaling Platelet Activation Rhodopsin Mediated Signaling Pathway System Development Cell Communication G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Signaling Wound Healing Dopamine Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Locomotion Response To Stimulus Response To Wounding Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Multicellular Organismal Development Regulation Of Catalytic Activity Cellular Response To Stimulus
Tagcloud ?		adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic	adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital
Tagcloud (Difference) ?		adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic	adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital
Tagcloud (Intersection) ?