FLNC and KY

Number of citations of the paper that reports this interaction (PubMedID 15385448)
0

Data Source:
HPRD (two hybrid, in vitro)

		FLNC	KY
Description		filamin C	kyphoscoliosis peptidase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Sarcoplasm Z Disc Sarcolemma Costamere Intercellular Bridge	Cytoplasm Cytoskeleton Z Disc
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Identical Protein Binding Actin Filament Binding	Peptidase Activity Hydrolase Activity
	Biological Process	Actin Cytoskeleton Organization Sarcomere Organization Muscle Cell Development	Proteolysis Muscle Organ Development Neuromuscular Junction Development
Pathways		Cell-extracellular matrix interactions
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	1 interacting genes: FLNC
Entrez ID		2318	339855
HPRD ID		00018	13953
Ensembl ID		ENSG00000128591	ENSG00000174611
Uniprot IDs		Q14315 Q59H94	Q8NBH2
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX 7OUU 7OUV 7P0E 8PA0
Enriched GO Terms of Interacting Partners?		Z Disc Alpha1-adrenergic Receptor Activity Actin Binding Neuron-glial Cell Signaling Actin Filament-based Process FATZ Binding Heart Contraction Telethonin Binding Actin Cytoskeleton Organization Heart Process Adrenergic Receptor Activity Sarcomere Organization Cytoplasm Circulatory System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-actinin Binding Striated Muscle Tissue Development Muscle Structure Development Adrenergic Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Regulation Of System Process Muscle Tissue Development Anchoring Junction M Band Cytoskeleton Organization Dystroglycan Complex Supramolecular Fiber Organization Muscle Contraction Sarcoglycan Complex Actomyosin Structure Organization Regulation Of Intracellular Signal Transduction Structural Constituent Of Muscle System Process Regulation Of Signal Transduction Regulation Of Skeletal Muscle Tissue Regeneration Muscle Organ Development Regulation Of Supramolecular Fiber Organization Regulation Of Muscle System Process Muscle System Process Regulation Of Actin Filament Organization Regulation Of Protein Processing Actin Cytoskeleton Regulation Of Protein Maturation Cardiac Muscle Tissue Development Titin Binding Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cytoskeleton Regulation Of Cell Communication	Costamere Ankyrin Binding Sarcoplasm Sarcomere Organization Sarcolemma Intercellular Bridge Muscle Cell Development Actomyosin Structure Organization Cytoskeletal Protein Binding Z Disc Actin Filament Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?