MAP1S and SOCS3

Number of citations of the paper that reports this interaction (PubMedID 19027008)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MAP1S	SOCS3
Description		microtubule associated protein 1S	suppressor of cytokine signaling 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Dendrite Cell Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Mitotic Spindle Microtubule	Cytosol Cytoplasmic Side Of Plasma Membrane
	Molecular Function	DNA Binding Actin Binding DNA Nuclease Activity Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding Beta-tubulin Binding Actin Filament Binding	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Cytokine Receptor Binding Protein Binding Protein Tyrosine Kinase Inhibitor Activity MiRNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Autophagy Apoptotic Process Mitotic Spindle Organization Nervous System Development Axonogenesis Brain Development Dendrite Development Regulation Of Microtubule Depolymerization Microtubule Anchoring At Centrosome Mitochondrion Transport Along Microtubule Neuron Projection Morphogenesis Metaphase Chromosome Alignment	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Interleukin-17 Cellular Response To Leukemia Inhibitory Factor
Pathways			Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Height ( 28552196)	Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)
Interacting Genes		15 interacting genes: ATM BPY2 BPY2C FILNC1 HDAC4 KCNJ6 LRPPRC MAP1LC3A NLGN3 PIN1 RASSF1 SLC2A4 SOCS3 SRPK2 VHL	66 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CAVIN1 CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET MEX3C NFATC2 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ
Entrez ID		55201	9021
HPRD ID		10461	05006
Ensembl ID		ENSG00000130479	ENSG00000184557
Uniprot IDs		Q66K74	O14543 Q6FI39
PDB IDs
Enriched GO Terms of Interacting Partners?		HECT Domain Binding Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Protein Stabilization Response To Decreased Oxygen Levels Response To Oxygen Levels Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Stability Cellular Response To Hypoxia Negative Regulation Of Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-serine Phosphorylation Cis-trans Isomerase Activity Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Receptor Complex Signal Transduction Protein Kinase Activity Kinase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Cell Communication Cytokine Binding Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Epidermal Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytokine Receptor Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process External Side Of Plasma Membrane Regulation Of Programmed Cell Death Protein Modification Process Erythropoietin-mediated Signaling Pathway Developmental Process Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Intracellular Signaling Cassette Cell Differentiation Positive Regulation Of Cell Motility Cellular Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Positive Regulation Of Locomotion Protein Autophosphorylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?