NR1D2 and NR1D1

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid)

		NR1D2	NR1D1
Gene Name		nuclear receptor subfamily 1, group D, member 2	nuclear receptor subfamily 1, group D, member 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Dendrite Dendritic Spine
	Molecular Function	Core Promoter Sequence-specific DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Binding Steroid Hormone Receptor Activity Transcription Corepressor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Heme Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Gene Expression Regulation Of Lipid Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process Regulation Of Inflammatory Response Lipid Homeostasis Regulation Of Energy Homeostasis Regulation Of Skeletal Muscle Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Glycogen Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Circadian Rhythm Gene Expression Proteasomal Protein Catabolic Process Negative Regulation Of Receptor Biosynthetic Process Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Response To Leptin Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Circadian Temperature Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Regulation Of Cholesterol Homeostasis Positive Regulation Of Cholesterol Homeostasis
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Generic Transcription Pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			White blood cell count ( 21738480)
Protein-Protein Interactions		19 interactors: CUL1 GTF2B HDAC1 KRT40 KRTAP10-9 KRTAP4-2 MID2 NCOA5 NCOR1 NOTCH2NL NR1D1 PRMT6 RBPMS RGN SIN3B TAF6 TAF9 TRIM27 UBE2I	7 interactors: APP C1D INPP1 NCOR1 NCOR2 NR1D2 NR2E3
Entrez ID		9975	9572
HPRD ID		03809	03873
Ensembl ID		ENSG00000174738	ENSG00000126368
Uniprot IDs		B4DXD3 F1D8P2 Q14995 Q6NSM0	F1D8S3 P20393
PDB IDs		2V0V 2V7C 3CQV	1A6Y 1EF6 1GA5 1HLZ 3N00
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Viral Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Viral Transcription Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Notch Signaling Pathway Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Negative Regulation Of Viral Process Regulation Of Cellular Process Circadian Regulation Of Gene Expression Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Elongation Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Modification Rhythmic Process Negative Regulation Of Viral Release From Host Cell Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Receptor Biosynthetic Process Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Release From Host Cell Histone Modification	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Chemical Homeostasis Transcription From RNA Polymerase II Promoter Gene Expression Rhythmic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Forebrain Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Lipid Metabolic Process Response To Steroid Hormone Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Homeostatic Process Regulation Of Multicellular Organism Growth Steroid Hormone Mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Lipid Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Signal Transduction Hormone-mediated Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Positive Regulation Of Rhodopsin Gene Expression CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Nitrogen Compound Metabolic Process Signaling Brain Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance
Tagcloud ?		adopting af2 arrangement bend bulky cavity circadian clock closing cognate conformation dimeric erb erbalpha erbbeta filled filling flexibility geometry h11 helix hydrophobic kinked lbp orphan pocket putative rev stabilize	arntl2 atlantic clock clocks cry1b cry2 cry3 cryptochrome gadus kaput mbnl1 minded morhua muscleblind myf5 npas1 npas2 nr1d2a ontogenesis oscillators per2a per2b rhythmicity rora synteny teleosts tetrapods timeless translocator
Tagcloud (Difference) ?		adopting af2 arrangement bend bulky cavity circadian closing cognate conformation dimeric erb erbalpha erbbeta filled filling flexibility geometry h11 helix hydrophobic kinked lbp orphan pocket putative rev stabilize	arntl2 atlantic clocks cry1b cry2 cry3 cryptochrome gadus kaput mbnl1 minded morhua muscleblind myf5 npas1 npas2 nr1d2a ontogenesis oscillators per2a per2b rhythmicity rora synteny teleosts tetrapods timeless translocator
Tagcloud (Intersection) ?		clock