PEX7 and PHYH

Number of citations: 0 (PubMedID 9326939)
Data Source: HPRD (two hybrid)

		PEX7	PHYH
Name		peroxisomal biogenesis factor 7	phytanoyl-CoA 2-hydroxylase
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol	Peroxisome Peroxisomal Matrix Cytosol 9+0 Non-motile Cilium
	Molecular Function	Peroxisome Matrix Targeting Signal-2 Binding Protein Binding Enzyme Binding Protein Homodimerization Activity	Catalytic Activity Protein Binding Ferrous Iron Binding Oxidoreductase Activity Carboxylic Acid Binding L-ascorbic Acid Binding Metal Ion Binding Phytanoyl-CoA Dioxygenase Activity Dioxygenase Activity
	Biological Process	Neuron Migration Endochondral Ossification Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Peroxisome Organization Ether Lipid Biosynthetic Process Protein Transport Protein Import Into Peroxisome Matrix	Fatty Acid Alpha-oxidation 2-oxoglutarate Metabolic Process Fatty Acid Metabolic Process Isoprenoid Metabolic Process 2-oxobutyrate Catabolic Process Methyl-branched Fatty Acid Metabolic Process
Pathways		Peroxisomal protein import Peroxisomal protein import	Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		None	Antihemophilic factor, human recombinant Ascorbic acid Lonoctocog alfa Moroctocog alfa
Diseases		Refsum disease; Heredopathia atactica polyneuritiformis Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	Refsum disease; Heredopathia atactica polyneuritiformis
GWAS		Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Lymphocyte percentage of white cells ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 32888494 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: ACAT1 KDM1A PEX13 PEX14 PEX5 PEX5L PHYH PRMT6	11 interacting genes: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PATJ PEX7 PHYHIP SIRPA TOM1L1
Entrez ID		5191	5264
HPRD ID		03454	03609
Ensembl ID		ENSG00000112357	ENSG00000107537
Uniprot IDs		A0A7I2V2J8 O00628 Q6FGN1	O14832
PDB IDs		Not available	2A1X
GO Terms Enriched among Interactors		Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Peroxisomal Membrane Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Organization Receptor Recycling Peroxisome Intracellular Protein Transmembrane Transport Lipid Modification Peroxisomal Importomer Complex Peroxisome Targeting Sequence Binding Receptor Metabolic Process Protein Monoubiquitination Carboxylic Acid Catabolic Process Fatty Acid Alpha-oxidation Lipid Catabolic Process Protein Transmembrane Transport Fatty Acid Metabolic Process Cellular Response To Reactive Oxygen Species Small Molecule Metabolic Process Protein-containing Complex Disassembly Monocarboxylic Acid Metabolic Process Response To Reactive Oxygen Species Protein Transmembrane Transporter Activity Cerebral Cortex Cell Migration Cellular Response To Oxidative Stress Telencephalon Cell Migration Forebrain Cell Migration Carboxylic Acid Metabolic Process Cellular Response To Chemical Stress Peroxisomal Matrix Organic Acid Metabolic Process Fatty Acid Beta-oxidation Metanephric Proximal Convoluted Tubule Development Propionyl-CoA Biosynthetic Process C-acetyltransferase Activity Peroxisome Transport Along Microtubule 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity Lipid Localization Histone H2AR3 Methyltransferase Activity	None