PYGO1 and CARM1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		PYGO1	CARM1
Description		pygopus family PHD finger 1	coactivator associated arginine methyltransferase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Replication Fork
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity	Transcription Cis-regulatory Region Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Methyltransferase Activity Protein Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H3R17 Methyltransferase Activity Histone Methyltransferase Activity Histone H3R2 Methyltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Kidney Development Hematopoietic Progenitor Cell Differentiation Chromatin Organization Spermatid Development Spermatid Nucleus Differentiation Wnt Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process Positive Regulation Of Cell Population Proliferation Methylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase I Response To CAMP Replication Fork Reversal Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Dendrite Development
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545)	C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624)
Interacting Genes		6 interacting genes: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1	34 interacting genes: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 DZIP3 ELAVL1 EP300 FLII FOS GRIP1 H3-3A H3-3B H3C1 KDM1A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PRMT8 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRCAP TP53 UBE2I
Entrez ID		26108	10498
HPRD ID		06064	09158
Ensembl ID		ENSG00000171016	ENSG00000142453
Uniprot IDs		Q9Y3Y4	Q86X55
PDB IDs		2VP7 2VPB 2VPD 2VPE 2VPG	2Y1W 2Y1X 4IKP 5DWQ 5DX0 5DX1 5DX8 5DXA 5DXJ 5U4X 6ARJ 6ARV 6D2L 6DVR 6IZQ 6S70 6S71 6S74 6S77 6S79 6S7A 6S7B 6S7C 7FAI 7FAJ 7U9I 8G2H 8G2I 8SIG 8SIH
Enriched GO Terms of Interacting Partners?		Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Beta-catenin-TCF Complex Histone Methyltransferase Activity Transcription Coactivator Activity Regulation Of Cell Communication Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Signaling Maintenance Of Cell Number Muscle Cell Differentiation Canonical Wnt Signaling Pathway Stem Cell Population Maintenance Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Regulation Of Timing Of Anagen Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Protein-containing Complex Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Positive Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Transcription Coactivator Activity Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Enzyme Binding Muscle Cell Differentiation Positive Regulation Of Cell Differentiation RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Developmental Process Nuclear Androgen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Regulation Of Cell Development
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