PYGO1 and SPTBN1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PYGO1	SPTBN1
Gene Name		pygopus family PHD finger 1	spectrin, beta, non-erythrocytic 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleolus Cytoplasm Cytosol Spectrin Spectrin-associated Cytoskeleton Axolemma M Band Cuticular Plate Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein Complex Binding Poly(A) RNA Binding
	Biological Process	Kidney Development Hematopoietic Progenitor Cell Differentiation Spermatid Nucleus Differentiation Post-embryonic Development Wnt Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Transcription From RNA Polymerase II Promoter	Mitotic Cytokinesis Plasma Membrane Organization Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Axon Guidance Golgi To Plasma Membrane Protein Transport Actin Filament Capping Membrane Assembly Protein Targeting To Plasma Membrane
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex	Interaction between L1 and Ankyrins Axon guidance Nephrin interactions L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Bone mineral density (spine) ( 19079262 19801982 18445777) Myopia (pathological) ( 22685421)
Protein-Protein Interactions		6 interactors: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1	39 interactors: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 CPNE1 CPNE4 CSNK2A1 CTNNA1 DISC1 EPB41 EPB41L3 GRB2 GRIA2 MAPK14 MEF2C NF2 PACSIN1 PDE4D PJA1 PLCB1 PLEKHA5 PRKACA PYGO1 RINT1 SH3BP5 SMAD3 SMAD4 SMAD9 SNCA SPTAN1 SREBF2 STAT1 TNIK TRAF3IP1 YWHAG ZNF512B
Entrez ID		26108	6711
HPRD ID		06064	01683
Ensembl ID			ENSG00000115306
Uniprot IDs		A7Y2D6 Q9Y3Y4	B2ZZ89 Q01082
PDB IDs		2VP7 2VPB 2VPD 2VPE 2VPG	1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?		Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cartilage Development Canonical Wnt Signaling Pathway Histone H3-R17 Methylation Histone Methylation Stem Cell Maintenance Negative Regulation Of Mitotic Cell Cycle, Embryonic Myotube Differentiation Involved In Skeletal Muscle Regeneration Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Protein Methylation Regulation Of Organ Morphogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Intracellular Receptor Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Central Nervous System Vasculogenesis Trachea Formation Cellular Response To Indole-3-methanol Stem Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Common-partner SMAD Protein Phosphorylation Skeletal System Morphogenesis Wnt Signaling Pathway Negative Regulation Of Protein Sumoylation Positive Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic SMAD Protein Import Into Nucleus Stem Cell Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation	Regulation Of Cellular Component Organization System Development Intracellular Signal Transduction Nervous System Development Regulation Of Cellular Localization Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Regulation Of Phosphorylation Regulation Of Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell-cell Junction Organization Regulation Of Intracellular Transport Developmental Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Neurogenesis Negative Regulation Of Phosphorylation Apoptotic Process Signaling Anatomical Structure Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Development Organelle Organization Programmed Cell Death Cell Communication Generation Of Neurons Kidney Development Cell Death Cell Morphogenesis Death Regulation Of Protein Metabolic Process Cell-cell Junction Assembly Epithelium Development Cellular Response To Organonitrogen Compound Renal System Development Cell Activation Organ Development Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Metabolic Process Cell Projection Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Neuron Development
Tagcloud ?		analyze bioinformatic bioinformatics category chemical coil contained formula heart helix highest homeodomain hydrophilic hydrophobicity hyrdrophilicity isoelectric physical plant point progress proline random regulate residues secondary structure theoretical tools transmembrane	adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco
Tagcloud (Difference) ?		analyze bioinformatic bioinformatics category chemical coil contained formula heart helix highest homeodomain hydrophilic hydrophobicity hyrdrophilicity isoelectric physical plant point progress proline random regulate residues secondary structure theoretical tools transmembrane	adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco
Tagcloud (Intersection) ?