POLD1 and ADAMTSL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLD1	ADAMTSL4
Description		DNA polymerase delta 1, catalytic subunit	ADAMTS like 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex	Extracellular Region Interstitial Matrix Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Nuclease Activity Exonuclease Activity Protein Binding Zinc Ion Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Enzyme Binding DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protease Binding Protein Binding Identical Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Response To UV Cellular Response To UV DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process	Epithelial Cell Development Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process Pigment Cell Development
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases			Ectopia lentis
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)	Appendicular lean mass ( 33097823) Asthma ( 32296059) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Migraine ( 27322543) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		21 interacting genes: ADAMTSL4 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLD2 POLD3 POLD4 SUMO2 TREX2 TRIM55 WRNIP1 XRCC5 YPEL3	212 interacting genes: ADAM12 ADAMTSL5 ALPP AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 ATG9A BAG4 BANF2 BOLA2 BOLA2B BRME1 CATSPER1 CBX3 CCDC26 CFAP206 CHCHD2 CHERP CHIC2 CHRD CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 CYSRT1 DGCR6 DGCR6L DIP2A DLK2 DNPEP DSCR8 EFEMP2 EIF4E2 EPDR1 ERCC3 EXOSC5 FAH FAM124B FARS2 FBLN1 FBXL9P FBXO17 FBXW5 FHL3 FKBP1B FLNA FRS3 FXR1 GATA2 GIP GLRX3 GLYCTK GMCL2 GNE GNG13 GNMT GOLGA8EP GSTP1 GUCD1 HEXIM2 HGF HNRNPLL HOXA1 HOXC8 HSD3B7 INS IP6K1 ITGB2 ITGB4 JOSD1 KCTD7 KCTD9 KIF1A KLHL38 KRTAP1-1 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP21-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LGALS14 LHX4 LINC00671 LMO1 LMO2 LMO4 LNX1 LONRF1 LRFN4 MAGOHB MAPKBP1 MGAT5B MID2 MKRN3 MORN3 MVP MYLIP MYO15B NATD1 NBPF19 NEK8 NFKBID NMUR2 NOTCH2NLA NR4A3 NTAQ1 NTF4 NTN4 NUFIP2 OLFM3 OTX1 PCSK5 PID1 PIN1 PKN1 PLSCR1 PLSCR4 POLD1 POLR1C POU4F2 PRKAB2 PRR19 PTGER3 PTPMT1 QPRT R3HDM2 RAB2B RCHY1 RGL2 RHOJ RPS19BP1 RUNX1T1 SALL2 SCNM1 SHFL SLC13A5 SLC23A1 SLC6A20 SLIT1 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY1 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TFAP2D TGFB1 THAP6 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIM55 TRIM63 TRIP6 TSSK3 TUBGCP4 USP21 VASN VENTX VWC2 ZFHX2 ZNF330 ZNF414 ZNF417 ZNF587
Entrez ID		5424	54507
HPRD ID		08882	18237
Ensembl ID		ENSG00000062822	ENSG00000143382
Uniprot IDs		A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0	A0A669KBE7 B7ZMJ3 Q6UY14
PDB IDs		6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Repair DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA-templated DNA Replication DNA Damage Response DNA Strand Elongation Involved In DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Delta DNA Polymerase Complex DNA Strand Elongation Telomere Maintenance Telomere Organization Mitotic Cell Cycle Phase Transition Cyclin D3-CDK4 Complex Cellular Response To Stress Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome, Telomeric Region DNA-directed DNA Polymerase Activity G1/S Transition Of Mitotic Cell Cycle Translesion Synthesis Cell Cycle G1/S Phase Transition Cyclin E1-CDK2 Complex DNA Synthesis Involved In UV-damage Excision Repair Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Postreplication Repair Regulation Of DNA Replication Nucleoplasm Nucleobase-containing Compound Metabolic Process MutLalpha Complex Binding Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Chromosome Organization Protein Localization To Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process	Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Tissue Development Identical Protein Binding Hair Cycle
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