POLD1 and CDK4

Number of citations of the paper that reports this interaction (PMID 9545286)
2

Data Source:
BioGRID (enzymatic study)

		POLD1	CDK4
Gene Name		polymerase (DNA directed), delta 1, catalytic subunit	cyclin-dependent kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Membrane Aggresome Delta DNA Polymerase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Tight Junction Nuclear Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein Complex Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Catabolic Process, Exonucleolytic DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Response To UV Telomere Maintenance Via Semi-conservative Replication Small Molecule Metabolic Process DNA Replication Proofreading Fatty Acid Homeostasis	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Lens Development In Camera-type Eye Chromatin Organization Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Testosterone Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Response To Hyperoxia Negative Regulation Of Cell Cycle Arrest
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Cytosolic iron-sulfur cluster assembly Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)	Meiotic recombination Chromatin organization Ubiquitin-dependent degradation of Cyclin D Cellular Senescence G1 Phase Senescence-Associated Secretory Phenotype (SASP) S Phase Oncogene Induced Senescence Cell Cycle, Mitotic Ubiquitin-dependent degradation of Cyclin D1 RMTs methylate histone arginines Cyclin D associated events in G1 Chromatin modifying enzymes Oxidative Stress Induced Senescence Transcriptional regulation of white adipocyte differentiation Mitotic G1-G1/S phases
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Celiac disease and Rheumatoid arthritis ( 21383967)
Protein-Protein Interactions		16 interactors: ATR CCND3 CCNE1 CDK2 CDK4 CHGB GINS4 KIAA1377 PCNA POLD2 POLD3 POLD4 TERF2IP TREX2 WRNIP1 XRCC5	90 interactors: ANKRD12 ANXA7 APLP1 APP ARID4A ATP5B BAG6 BCL11A BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 DAZAP2 DDAH2 DUSP9 FOXM1 GLI1 H1F0 HIST1H1A HIST1H1D HMGXB3 HOOK1 IFI27 IL15RA LUC7L2 MAPRE2 MARCKS MCM2 MYC MYOD1 MZF1 NCOA2 NOL12 ORC3 OTX2 PGD PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA TGFBR1 TK1 TRMT2A TSPYL2 UBTF UHRF2 VTA1 WDR33 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655 ZSCAN1
Entrez ID		5424	1019
HPRD ID		08882	00447
Ensembl ID		ENSG00000062822	ENSG00000135446
Uniprot IDs		M0R2B7 P28340 Q59FA0	P11802 Q6LC83
PDB IDs			1LD2 2W96 2W99 2W9F 2W9Z 3G33
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Metabolic Process Telomere Maintenance DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Lengthening DNA Repair Cell Cycle DNA-dependent DNA Replication Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cell Cycle Process Mitotic Recombination Cellular Response To Stress DNA Recombination DNA Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Chromosome Organization Mismatch Repair Base-excision Repair Nucleotide-excision Repair Response To Stress Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cellular Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of DNA-dependent DNA Replication Initiation Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process DNA Synthesis Involved In DNA Repair Response To Stimulus Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cell Division Cellular Response To Ionizing Radiation Positive Regulation Of Deoxyribonuclease Activity	Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Gene Expression Regulation Of Cell Proliferation Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Gene Expression Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Phosphorylation Chromosome Organization Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process
Tagcloud ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt	aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned
Tagcloud (Difference) ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt	aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned
Tagcloud (Intersection) ?