POLD1 and TREX2

Number of citations of the paper that reports this interaction (PubMedID 12806015)
0

Data Source:
HPRD (in vitro)

		POLD1	TREX2
Description		DNA polymerase delta 1, catalytic subunit	three prime repair exonuclease 2
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Nuclease Activity Exonuclease Activity Protein Binding Zinc Ion Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Enzyme Binding DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Nuclease Activity Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Response To UV Cellular Response To UV DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process	DNA Metabolic Process DNA Repair DNA Catabolic Process DNA Damage Response
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		21 interacting genes: ADAMTSL4 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLD2 POLD3 POLD4 SUMO2 TREX2 TRIM55 WRNIP1 XRCC5 YPEL3	4 interacting genes: ATF4 MESD POLD1 UBE2N
Entrez ID		5424	11219
HPRD ID		08882	02299
Ensembl ID		ENSG00000062822	ENSG00000183479
Uniprot IDs		A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0	Q9BQ50
PDB IDs		6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB	1Y97
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Repair DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA-templated DNA Replication DNA Damage Response DNA Strand Elongation Involved In DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Delta DNA Polymerase Complex DNA Strand Elongation Telomere Maintenance Telomere Organization Mitotic Cell Cycle Phase Transition Cyclin D3-CDK4 Complex Cellular Response To Stress Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome, Telomeric Region DNA-directed DNA Polymerase Activity G1/S Transition Of Mitotic Cell Cycle Translesion Synthesis Cell Cycle G1/S Phase Transition Cyclin E1-CDK2 Complex DNA Synthesis Involved In UV-damage Excision Repair Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Postreplication Repair Regulation Of DNA Replication Nucleoplasm Nucleobase-containing Compound Metabolic Process MutLalpha Complex Binding Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Chromosome Organization Protein Localization To Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process	Postreplication Repair Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress Cellular Response To UV ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process Response To UV Cellular Response To Light Stimulus Cellular Response To Radiation CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport DNA Replication Proofreading UBC13-MMS2 Complex ATF4-CREB1 Transcription Factor Complex Asparagine Metabolic Process Delta DNA Polymerase Complex Ubiquitin Conjugating Enzyme Complex GDF15-GFRAL Signaling Pathway Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Sodium-dependent Phosphate Transport Error-free Translesion Synthesis Cellular Response To Nutrient Levels Nucleotide-excision Repair Complex Nucleotide-excision Repair, DNA Gap Filling HRI-mediated Signaling Lens Fiber Cell Morphogenesis Regulation Of Phosphate Transport Response To Light Stimulus Cellular Response To Manganese Ion Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Mitochondrial Respirasome Assembly CAMP Response Element Binding Protein Binding 3'-5'-DNA Exonuclease Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process PERK-mediated Unfolded Protein Response Leucine Zipper Domain Binding General Transcription Initiation Factor Binding Positive Regulation Of Receptor Clustering Cellular Response To Stress Cellular Response To Leucine Starvation Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Base-excision Repair, Gap-filling Regulation Of Protein K63-linked Ubiquitination Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Nuclear Periphery Response To Radiation
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