POLD1 and TREX2

Number of citations of the paper that reports this interaction (PMID 12806015)
6

Data Source:
HPRD (in vitro)

		POLD1	TREX2
Gene Name		polymerase (DNA directed), delta 1, catalytic subunit	three prime repair exonuclease 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Membrane Aggresome Delta DNA Polymerase Complex	Nucleus
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Magnesium Ion Binding Nucleic Acid Binding 3'-5'-exodeoxyribonuclease Activity Exodeoxyribonuclease III Activity Protein Homodimerization Activity
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Catabolic Process, Exonucleolytic DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Response To UV Telomere Maintenance Via Semi-conservative Replication Small Molecule Metabolic Process DNA Replication Proofreading Fatty Acid Homeostasis	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Repair
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Cytosolic iron-sulfur cluster assembly Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		16 interactors: ATR CCND3 CCNE1 CDK2 CDK4 CHGB GINS4 KIAA1377 PCNA POLD2 POLD3 POLD4 TERF2IP TREX2 WRNIP1 XRCC5	2 interactors: ATF4 POLD1
Entrez ID		5424	11219
HPRD ID		08882	02299
Ensembl ID		ENSG00000062822	ENSG00000183479
Uniprot IDs		M0R2B7 P28340 Q59FA0	Q9BQ50
PDB IDs			1Y97
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Metabolic Process Telomere Maintenance DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Lengthening DNA Repair Cell Cycle DNA-dependent DNA Replication Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cell Cycle Process Mitotic Recombination Cellular Response To Stress DNA Recombination DNA Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Chromosome Organization Mismatch Repair Base-excision Repair Nucleotide-excision Repair Response To Stress Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cellular Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of DNA-dependent DNA Replication Initiation Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process DNA Synthesis Involved In DNA Repair Response To Stimulus Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cell Division Cellular Response To Ionizing Radiation Positive Regulation Of Deoxyribonuclease Activity	DNA Replication Proofreading Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Base-excision Repair, Gap-filling Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase I Promoter Fatty Acid Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Potassium Ion Transport Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To Glucose Starvation Negative Regulation Of Oxidative Stress-induced Cell Death Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Gamma-aminobutyric Acid Signaling Pathway Telomere Maintenance Via Telomere Lengthening Positive Regulation Vascular Endothelial Growth Factor Production DNA Catabolic Process, Exonucleolytic Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Transcription-coupled Nucleotide-excision Repair Anion Homeostasis Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Oxidative Stress Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Gluconeogenesis Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Mismatch Repair Base-excision Repair Hexose Biosynthetic Process Positive Regulation Of Neuron Death Telomere Maintenance Circadian Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Nucleotide-excision Repair Negative Regulation Of Ion Transport Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway
Tagcloud ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt
Tagcloud (Difference) ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt
Tagcloud (Intersection) ?