POLD1 and CHGB

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLD1	CHGB
Gene Name		polymerase (DNA directed), delta 1, catalytic subunit	chromogranin B (secretogranin 1)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Membrane Aggresome Delta DNA Polymerase Complex	Extracellular Region Secretory Granule
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Hormone Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Catabolic Process, Exonucleolytic DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Response To UV Telomere Maintenance Via Semi-conservative Replication Small Molecule Metabolic Process DNA Replication Proofreading Fatty Acid Homeostasis
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Cytosolic iron-sulfur cluster assembly Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		16 interactors: ATR CCND3 CCNE1 CDK2 CDK4 CHGB GINS4 KIAA1377 PCNA POLD2 POLD3 POLD4 TERF2IP TREX2 WRNIP1 XRCC5	31 interactors: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 MARK3 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SGK223 SLC25A6 TAZ TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1
Entrez ID		5424	1114
HPRD ID		08882	07512
Ensembl ID		ENSG00000062822	ENSG00000089199
Uniprot IDs		M0R2B7 P28340 Q59FA0	P05060
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Metabolic Process Telomere Maintenance DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Lengthening DNA Repair Cell Cycle DNA-dependent DNA Replication Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cell Cycle Process Mitotic Recombination Cellular Response To Stress DNA Recombination DNA Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Chromosome Organization Mismatch Repair Base-excision Repair Nucleotide-excision Repair Response To Stress Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cellular Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of DNA-dependent DNA Replication Initiation Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process DNA Synthesis Involved In DNA Repair Response To Stimulus Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cell Division Cellular Response To Ionizing Radiation Positive Regulation Of Deoxyribonuclease Activity	Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Developmental Growth Cellular Metabolic Process Cellular Component Assembly Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Cell Differentiation Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Synaptic Transmission Response To Metal Ion Response To Lipid Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Regulation Of Cell Development Generation Of Neurons Response To Growth Factor Phosphate-containing Compound Metabolic Process Response To Organic Cyclic Compound Protein Homotetramerization Platelet Activation Positive Regulation Of Metabolic Process Response To Stress Metabolic Process Neurogenesis Response To Organic Substance Positive Regulation Of Lamellipodium Assembly Cellular Process Apoptotic Process Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Defense Response Hemostasis DNA-templated Transcription, Initiation Negative Regulation Of Developmental Growth Response To Wounding Long Term Synaptic Depression Programmed Cell Death Regulation Of Neurogenesis Nucleotide-excision Repair Positive Regulation Of Lamellipodium Organization Negative Regulation Of Growth Cell Death Death Cell Development Regulation Of Protein Import Into Nucleus, Translocation Developmental Process Regulation Of Cell Morphogenesis Response To Inorganic Substance
Tagcloud ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt	adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von
Tagcloud (Difference) ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt	adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von
Tagcloud (Intersection) ?