POLD1 and CCND3

Number of citations of the paper that reports this interaction (PMID 9545286)
2

Data Source:
BioGRID (enzymatic study)

		POLD1	CCND3
Gene Name		polymerase (DNA directed), delta 1, catalytic subunit	cyclin D3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Membrane Aggresome Delta DNA Polymerase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Membrane
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Catabolic Process, Exonucleolytic DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Response To UV Telomere Maintenance Via Semi-conservative Replication Small Molecule Metabolic Process DNA Replication Proofreading Fatty Acid Homeostasis	Positive Regulation Of Protein Phosphorylation Cell Cycle Signal Transduction T Cell Proliferation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Cytosolic iron-sulfur cluster assembly Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)	Cyclin D associated events in G1 Transcriptional regulation of white adipocyte differentiation G1 Phase Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 20139978 19862010) Mean corpuscular volume ( 23263863 20139978 19862010) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Neutrophil count ( 21507922) Red blood cell count ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		16 interactors: ATR CCND3 CCNE1 CDK2 CDK4 CHGB GINS4 KIAA1377 PCNA POLD2 POLD3 POLD4 TERF2IP TREX2 WRNIP1 XRCC5	38 interactors: AKAP8 APP AREG ATF5 ATP5C1 CASP2 CDK11B CDK14 CDK4 CDK6 CDKN1A CDKN1B CRABP2 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS GC MAF1 MAPK4 MAPK6 MCM10 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL RARA RB1 RBL2 RUNX1 SIL1 TFIP11 VDR
Entrez ID		5424	896
HPRD ID		08882	00452
Ensembl ID		ENSG00000062822	ENSG00000112576
Uniprot IDs		M0R2B7 P28340 Q59FA0	P30281 Q5T8J1
PDB IDs			3G33
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Metabolic Process Telomere Maintenance DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Lengthening DNA Repair Cell Cycle DNA-dependent DNA Replication Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cell Cycle Process Mitotic Recombination Cellular Response To Stress DNA Recombination DNA Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Chromosome Organization Mismatch Repair Base-excision Repair Nucleotide-excision Repair Response To Stress Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cellular Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of DNA-dependent DNA Replication Initiation Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process DNA Synthesis Involved In DNA Repair Response To Stimulus Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cell Division Cellular Response To Ionizing Radiation Positive Regulation Of Deoxyribonuclease Activity	Mitotic Cell Cycle Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Process Cellular Metabolic Process Organ Development Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process System Development Response To Steroid Hormone Positive Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Process Anatomical Structure Development Regulation Of Cell Cycle Phase Transition Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Response To Lipid Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Metabolic Process Regulation Of Myeloid Cell Differentiation Response To Stimulus Developmental Process Response To Hormone Positive Regulation Of Macromolecule Biosynthetic Process Response To Hyperoxia Cellular Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Kinase Activity Response To Abiotic Stimulus Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle
Tagcloud ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt	abi1 atlas bitbucket ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt	abi1 atlas bitbucket ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?