PMS2 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		PMS2	CRYAA
Description		PMS1 homolog 2, mismatch repair system component	crystallin alpha A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Mismatch Repair Complex MutLalpha Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Mismatched DNA Binding Single Base Insertion Or Deletion Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Response To Xenobiotic Stimulus Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS			Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		18 interacting genes: AKT1 ANP32B CCDC180 CRYAA EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC VPS26C XPA ZNF189	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		5395	1409
HPRD ID		02598	00427
Ensembl ID		ENSG00000122512	ENSG00000160202
Uniprot IDs		A0A2R8Y6S3 A0A8V8TNX6 A0A8V8TNY8 A0A8V8TP61 A0A8V8TP84 A0A8V8TPE1 A0A8V8TQ50 A0A8V8TQ92 A0A8V8TQG9 A0A8V8TQI1 A0A8V8TQS5 B4DGM0 C9J167 P54278	A0A8C8KJZ9 P02489
PDB IDs		1EA6 1H7S 1H7U 5U5R 6MFQ 7RCB 7RCI 7RCK	6T1R
Enriched GO Terms of Interacting Partners?		Response To Oxidative Stress Positive Regulation Of Deoxyribonuclease Activity Mismatch Repair Response To UV Response To UV-A Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Hydrogen Peroxide DNA Repair Response To Light Stimulus Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Stress Enzyme Binding TRNA Methylation Nucleus Regulation Of TRNA Methylation Response To Radiation Response To Reactive Oxygen Species DNA Metabolic Process DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Late Recombination Nodule Somatic Diversification Of Immunoglobulins Meiotic Metaphase I Homologous Chromosome Alignment PCNA Complex Replisome Negative Regulation Of Sodium-dependent Phosphate Transport Nucleotide-excision Repair, DNA Damage Recognition Double-stranded DNA 5'-3' DNA Exonuclease Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity Male Germ Cell Nucleus Nucleotide-excision Repair	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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