PMS2

Gene Name		PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton MutLalpha Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding
	Biological Process	DNA Repair Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: EXO1 MLH1 PCNA
Entrez ID		5395
HPRD ID		02598
Ensembl ID		ENSG00000122512
Uniprot IDs		P54278
PDB IDs		1EA6 1H7S 1H7U
Enriched GO Terms of Interacting Partners?		Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation DNA Recombination Isotype Switching Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Repair Immunoglobulin Production Cellular Response To DNA Damage Stimulus DNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Leukocyte Activation Involved In Immune Response B Cell Activation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Cell Cycle Meiotic Cell Cycle Negative Regulation Of Mitotic Recombination Leading Strand Elongation Cellular Response To Stress Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Lymphocyte Activation Spindle Midzone Assembly Aromatic Compound Catabolic Process Leukocyte Activation Translesion Synthesis Resolution Of Meiotic Recombination Intermediates Nucleotide-excision Repair, DNA Gap Filling Cell Activation Telomere Maintenance Via Semi-conservative Replication RNA Metabolic Process Immune System Development Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Stress
Tagcloud ?		additive agents alkylating alters biopsies brafv600e driving fotemustine genotoxic initially kill killed melanoma metastatic mgmt mlh1 msh2 msh6 necessitates question raf reasonable refractory requirement sequential subgroup synergistically temozolomide vemurafenib