PMS2 and EXO1

Number of citations of the paper that reports this interaction (PMID 11427529)
31

Data Source:
HPRD (in vivo, in vitro)

		PMS2	EXO1
Gene Name		PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	exonuclease 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton MutLalpha Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding	DNA Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity Structure-specific DNA Binding Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity
	Biological Process	DNA Repair Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS			Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		3 interactors: EXO1 MLH1 PCNA	15 interactors: ATM KPNA4 KPNB1 MLH1 MSH2 MSH3 PCNA PMS2 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5395	9156
HPRD ID		02598	06932
Ensembl ID		ENSG00000122512	ENSG00000174371
Uniprot IDs		P54278	Q9UQ84
PDB IDs		1EA6 1H7S 1H7U	3QE9 3QEA 3QEB
Enriched GO Terms of Interacting Partners?		Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation DNA Recombination Isotype Switching Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Repair Immunoglobulin Production Cellular Response To DNA Damage Stimulus DNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Leukocyte Activation Involved In Immune Response B Cell Activation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Cell Cycle Meiotic Cell Cycle Negative Regulation Of Mitotic Recombination Leading Strand Elongation Cellular Response To Stress Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Lymphocyte Activation Spindle Midzone Assembly Aromatic Compound Catabolic Process Leukocyte Activation Translesion Synthesis Resolution Of Meiotic Recombination Intermediates Nucleotide-excision Repair, DNA Gap Filling Cell Activation Telomere Maintenance Via Semi-conservative Replication RNA Metabolic Process Immune System Development Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Stress	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Mismatch Repair Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Organelle Organization Protein Targeting DNA Recombination Regulation Of Intracellular Transport Somatic Recombination Of Immunoglobulin Gene Segments Cellular Response To Stimulus Somatic Diversification Of Immunoglobulins Intracellular Signal Transduction Intracellular Protein Transport Regulation Of Apoptotic Process Immunoglobulin Production Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Stimulus Positive Regulation Of Transport Regulation Of Protein Localization System Development Negative Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Signal Transduction Cellular Response To DNA Damage Stimulus Membrane Organization Response To Stress Cellular Protein Localization Meiosis I Regulation Of Cellular Component Organization Protein Transport Establishment Of Localization In Cell DNA Repair Establishment Of Protein Localization
Tagcloud ?		additive agents alkylating alters biopsies brafv600e driving fotemustine genotoxic initially kill killed melanoma metastatic mgmt mlh1 msh2 msh6 necessitates question raf reasonable refractory requirement sequential subgroup synergistically temozolomide vemurafenib	break dephospho dsb exonuclease forks helicase hu hydroxyurea hypermorphs mec1 mimicking mispaired mlh1 mmr mms msh2 nucleases pol32 pol32delta polymerases rad2 rad53 s372 s567 s587 s692 sgs1 stalled zeta
Tagcloud (Difference) ?		additive agents alkylating alters biopsies brafv600e driving fotemustine genotoxic initially kill killed melanoma metastatic mgmt msh6 necessitates question raf reasonable refractory requirement sequential subgroup synergistically temozolomide vemurafenib	break dephospho dsb exonuclease forks helicase hu hydroxyurea hypermorphs mec1 mimicking mispaired mmr mms nucleases pol32 pol32delta polymerases rad2 rad53 s372 s567 s587 s692 sgs1 stalled zeta
Tagcloud (Intersection) ?		mlh1 msh2