PLP2 and VKORC1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		PLP2	VKORC1
Gene Name		proteolipid protein 2 (colonic epithelium-enriched)	vitamin K epoxide reductase complex, subunit 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ion Transmembrane Transporter Activity Chemokine Binding	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Ion Transmembrane Transport	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development
Pathways			Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs			Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS			Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		9 interactors: BCAP31 CCDC155 CCR1 CLN8 DLGAP4 IKBKAP SHBG TMEM79 VKORC1	80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB
Entrez ID		5355	79001
HPRD ID		02121	10540
Ensembl ID		ENSG00000102007	ENSG00000167397
Uniprot IDs		Q04941	Q9BQB6
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Localization To Nuclear Envelope Involved In Synapsis Primary Spermatocyte Growth Spermatogenesis Male Gamete Generation L-glutamate Uptake Involved In Synaptic Transmission Homeostatic Process Cuticle Development Gamete Generation Cornification Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Age-dependent Response To Oxidative Stress Protein Localization To Endoplasmic Reticulum Exit Site Vitamin K Metabolic Process Sexual Reproduction Multicellular Organismal Reproductive Process Somatic Motor Neuron Differentiation Multicellular Organism Reproduction L-glutamate Import Chemical Homeostasis Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Monocyte Chemotaxis Establishment Of Localization In Cell Neurotransmitter Uptake Calcium-mediated Signaling Using Intracellular Calcium Source Peptidyl-glutamic Acid Carboxylation Cellular Calcium Ion Homeostasis Regulation Of Monocyte Chemotaxis Dendritic Cell Chemotaxis Neurofilament Cytoskeleton Organization Reproduction Calcium Ion Homeostasis Neuromuscular Process Controlling Posture Amino Acid Import Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Mitochondrial Calcium Ion Homeostasis Establishment Of Skin Barrier Exocytosis Positive Regulation Of Cellular Component Movement	Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport
Tagcloud ?		antiviral bona coronavirus coronaviruses deubiquitinates engages ensure escape fide hcov ifnbeta immunopathology innate interferon irf7 mdm2 meanwhile nl63 nonstructural oncoprotein papain plps proteases proteasomal rampant reveals stabilizes suppressors usually	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Difference) ?		antiviral bona coronavirus coronaviruses deubiquitinates engages ensure escape fide hcov ifnbeta immunopathology innate interferon irf7 mdm2 meanwhile nl63 nonstructural oncoprotein papain plps proteases proteasomal rampant reveals stabilizes suppressors usually	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Intersection) ?