VKORC1 and PPIB

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		VKORC1	PPIB
Description		vitamin K epoxide reductase complex subunit 1	peptidylprolyl isomerase B
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Isomerase Activity Unfolded Protein Binding RNA Polymerase Binding
	Biological Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development	Protein Folding Neutrophil Chemotaxis Positive Regulation Of Multicellular Organism Growth Host-mediated Activation Of Viral Process Host-mediated Activation Of Viral Genome Replication Protein Stabilization Bone Development Regulation Of Post-translational Protein Modification
Pathways		Metabolism of vitamin K	Collagen biosynthesis and modifying enzymes SARS-CoV-1 activates/modulates innate immune responses
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol	Proline 1,4-Dithiothreitol
Diseases		Combined deficiency of vitamin K-dependent clotting factors (VKCFD)	Osteogenesis imperfecta
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24	24 interacting genes: APOB ATP12A BANP CAMLG CEBPA DNM2 ESR1 GLP1R H3-4 HSPA6 IRF3 MDM2 PEX19 PRH1 PRL SGTA SGTB STAT5A TP53 TRDN UBQLN1 UBQLN2 UBQLN4 VKORC1
Entrez ID		79001	5479
HPRD ID		10540	00458
Ensembl ID		ENSG00000167397	ENSG00000166794
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	P23284
PDB IDs		6WV3 6WV4 6WV5 6WV6 6WV7 6WVH	1CYN 3ICH 3ICI 8K0F 8K0I 8K0M 8K17 8KC9
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport	Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding TRC Complex Positive Regulation Of ERAD Pathway Regulation Of MiRNA Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Actinomycin D Regulation Of ERAD Pathway Protein-containing Complex Regulation Of MiRNA Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Actinomycin D Cellular Response To UV-C Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leukocyte Apoptotic Process Negative Regulation Of Proteolysis Autophagy Positive Regulation Of MiRNA Transcription Cellular Response To Antibiotic Regulation Of Cellular Response To Stress Response To Estrogen Positive Regulation Of MiRNA Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Macromolecule Metabolic Process Response To Stress Cardiac Septum Morphogenesis Regulation Of Macroautophagy Response To UV-C Establishment Of Protein Localization To Membrane Response To Hormone Autophagosome Tail-anchored Membrane Protein Insertion Into ER Membrane Cellular Response To Stress Enzyme Binding Myeloid Cell Apoptotic Process Cellular Response To Estrogen Stimulus Cytokine-mediated Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress ERAD Pathway
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