VKORC1 and ATP6AP2

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	ATP6AP2
Gene Name		vitamin K epoxide reductase complex, subunit 1	ATPase, H+ transporting, lysosomal accessory protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Neuron Projection Cell Body Extracellular Vesicular Exosome
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Aspartic-type Endopeptidase Activity Receptor Activity Protein Binding Enzyme Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Angiotensin Maturation Proteolysis Rostrocaudal Neural Tube Patterning Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta1 Production Regulation Of MAPK Cascade Cellular Protein Metabolic Process Eye Pigmentation Head Morphogenesis
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	4 interactors: AGT REN VKORC1 ZBTB16
Entrez ID		79001	10159
HPRD ID		10540	06454
Ensembl ID		ENSG00000167397	ENSG00000182220
Uniprot IDs		Q9BQB6	B7Z1I9 B7Z413 B7Z9I3 O75787
PDB IDs			3LBS 3LC8
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Renin-angiotensin Regulation Of Aldosterone Production Drinking Behavior Mesonephros Development Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Blood Volume By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Kidney Development Renal System Development Peptide Hormone Processing Urogenital System Development Negative Regulation Of Cell Proliferation Regulation Of Systemic Arterial Blood Pressure Renal System Process Feeding Behavior Developmental Process Involved In Reproduction Uterine Smooth Muscle Contraction Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Cell Differentiation Peptide Metabolic Process Organ Development Protein Localization To Nucleus Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Protein Kinase C Activity Catenin Import Into Nucleus Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of Blood Pressure Hormone Metabolic Process Angiotensin-mediated Drinking Behavior Smooth Muscle Cell Proliferation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Extracellular Matrix Constituent Secretion G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Ovarian Follicle Rupture Regulation Of Renal Output By Angiotensin Single Organism Reproductive Process Gonad Development Development Of Primary Sexual Characteristics Protein Processing Fibroblast Proliferation Astrocyte Activation Reproductive Process Cellular Amide Metabolic Process Regulation Of Hormone Levels Positive Regulation Of NK T Cell Differentiation Regulation Of Blood Vessel Size By Renin-angiotensin Sex Differentiation Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Activation Of JAK2 Kinase Activity
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	amnion beta1 born endoperoxide fetal finger glucocorticoids integrity intrauterine labor maintaining membranes namely postulated preterm profibrotic promyelocytic prorenin prostaglandin ptgs2 regulate regulators renin sex stimulate synthase tgfb1 transforming zinc
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	amnion beta1 born endoperoxide fetal finger glucocorticoids integrity intrauterine labor maintaining membranes namely postulated preterm profibrotic promyelocytic prorenin prostaglandin ptgs2 regulate regulators renin sex stimulate synthase tgfb1 transforming zinc
Tagcloud (Intersection) ?