VKORC1 and AHSG

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		VKORC1	AHSG
Description		vitamin K epoxide reductase complex subunit 1	alpha 2-HS glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Kinase Inhibitor Activity
	Biological Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development	Skeletal System Development Ossification Pinocytosis Acute-phase Response Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis
Pathways		Metabolism of vitamin K	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576)
Interacting Genes		93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24	9 interacting genes: CDC42 DCN FBXO2 FBXW7 GRB2 HSP90AA1 INSR RRAS2 VKORC1
Entrez ID		79001	197
HPRD ID		10540	00727
Ensembl ID		ENSG00000167397	ENSG00000145192
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	C9JV77 P02765
PDB IDs		6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport	Positive Regulation Of Organelle Organization GTP Binding Insulin Receptor Substrate Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Assembly Neuron Projection Organization Regulation Of Lamellipodium Assembly Dendritic Spine Organization Postsynapse Organization Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Post-translational Protein Modification Small GTPase-mediated Signal Transduction Regulation Of Lamellipodium Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Receptor Internalization Regulation Of Cell Migration Neuronal Cell Body GBD Domain Binding Storage Vacuole Identical Protein Binding Lysosomal Lumen Positive Regulation Of Protein Polymerization Protein Phosphatase Binding Insulin Receptor Signaling Pathway Grb2-EGFR Complex Ras Protein Signal Transduction Regulation Of Protein Catabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Amyloid-beta Binding Denatured Protein Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity
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