PLP2 and CCR1

Number of citations of the paper that reports this interaction (PMID 15474493)
4

Data Source:
HPRD (in vivo, two hybrid)

		PLP2	CCR1
Gene Name		proteolipid protein 2 (colonic epithelium-enriched)	chemokine (C-C motif) receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Binding Ion Transmembrane Transporter Activity Chemokine Binding	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Ion Transmembrane Transport	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Metabolic Process Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140)
Protein-Protein Interactions		9 interactors: BCAP31 CCDC155 CCR1 CLN8 DLGAP4 IKBKAP SHBG TMEM79 VKORC1	20 interactors: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2
Entrez ID		5355	1230
HPRD ID		02121	03101
Ensembl ID		ENSG00000102007	ENSG00000163823
Uniprot IDs		Q04941	P32246 Q5U003
PDB IDs			1Y5D
Enriched GO Terms of Interacting Partners?		Chromosome Localization To Nuclear Envelope Involved In Synapsis Primary Spermatocyte Growth Spermatogenesis Male Gamete Generation L-glutamate Uptake Involved In Synaptic Transmission Homeostatic Process Cuticle Development Gamete Generation Cornification Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Age-dependent Response To Oxidative Stress Protein Localization To Endoplasmic Reticulum Exit Site Vitamin K Metabolic Process Sexual Reproduction Multicellular Organismal Reproductive Process Somatic Motor Neuron Differentiation Multicellular Organism Reproduction L-glutamate Import Chemical Homeostasis Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Monocyte Chemotaxis Establishment Of Localization In Cell Neurotransmitter Uptake Calcium-mediated Signaling Using Intracellular Calcium Source Peptidyl-glutamic Acid Carboxylation Cellular Calcium Ion Homeostasis Regulation Of Monocyte Chemotaxis Dendritic Cell Chemotaxis Neurofilament Cytoskeleton Organization Reproduction Calcium Ion Homeostasis Neuromuscular Process Controlling Posture Amino Acid Import Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Mitochondrial Calcium Ion Homeostasis Establishment Of Skin Barrier Exocytosis Positive Regulation Of Cellular Component Movement	Cell Chemotaxis Chemotaxis Inflammatory Response Locomotion Cell Migration Cell Motility Immune Response Defense Response Response To External Stimulus Movement Of Cell Or Subcellular Component Monocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Cellular Calcium Ion Homeostasis Immune System Process Calcium Ion Homeostasis Positive Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Chemical Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Chemotaxis Regulation Of Behavior Positive Regulation Of Cellular Component Movement Ion Homeostasis Positive Regulation Of Locomotion Cellular Response To Stimulus Positive Regulation Of Calcium Ion Transport Regulation Of Cell Migration Cell-cell Signaling Regulation Of Cell Motility Leukocyte Chemotaxis Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Eosinophil Chemotaxis Regulation Of Locomotion Homeostatic Process Regulation Of Cellular Component Movement Eosinophil Migration Cellular Homeostasis
Tagcloud ?		antiviral bona coronavirus coronaviruses deubiquitinates engages ensure escape fide hcov ifnbeta immunopathology innate interferon irf7 mdm2 meanwhile nl63 nonstructural oncoprotein papain plps proteases proteasomal rampant reveals stabilizes suppressors usually	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		antiviral bona coronavirus coronaviruses deubiquitinates engages ensure escape fide hcov ifnbeta immunopathology innate interferon irf7 mdm2 meanwhile nl63 nonstructural oncoprotein papain plps proteases proteasomal rampant reveals stabilizes suppressors usually	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?