PLP2 and ELOVL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLP2	ELOVL5
Description		proteolipid protein 2	ELOVL fatty acid elongase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dendrite Cell Projection Neuronal Cell Body Dendritic Tree
	Molecular Function	Protein Binding Monoatomic Ion Transmembrane Transporter Activity Chemokine Binding	Protein Binding Fatty Acid Elongase Activity Transferase Activity
	Biological Process	Monoatomic Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Monoatomic Ion Transmembrane Transport	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways			Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs			alpha-Linolenic acid
Diseases
GWAS		Platelet distribution width ( 32888494)	Cerebrospinal fluid AB1-42 levels ( 26252872) Daytime sleep phenotypes ( 27126917) Familial squamous cell lung carcinoma ( 29924316) Glaucoma ( 20363506) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Survival in colorectal cancer (distant metastatic) ( 26586795)
Interacting Genes		79 interacting genes: AQP2 AQP3 AQP6 AQP8 ARFIP2 ARL13B ASGR2 ATP5PF BCAP31 BIK BNIP3 CCR1 CD53 CD79A CERS4 CIAO2A CLDN5 CLN8 CPLX4 CRB3 CREB3L1 CYB561 CYBC1 CYBRD1 DARS2 DLGAP4 DNAJC1 EBP ELOVL5 ELP1 EVI2A FAM209A FAM210B FATE1 FCER1G FKBP7 FNDC9 GPR151 GPX8 HSBP1L1 HSD17B11 HSD17B13 KASH5 LHFPL1 LHFPL5 LMNA LRRC4C MGST3 MUC1 NDRG4 PACC1 PDZK1IP1 PIGP PSCA PTGES PVR REEP4 RETREG3 RNF5 SAR1A SCN3B SGPL1 SHBG SLC10A6 SLC14A2 SLC18A1 SLC2A13 SLC35H1 SPG21 SPN THAP4 TM4SF19 TMEM14B TMEM31 TMEM51 TMEM79 TMPRSS2 TMX2 VKORC1	14 interacting genes: GOSR2 HMOX1 HTR4 IGFBP5 NINJ2 PLP2 SLC39A9 STX7 SYNJ2BP SYS1 THSD7A TMEM243 TSNARE1 UBC
Entrez ID		5355	60481
HPRD ID		02121	13268
Ensembl ID		ENSG00000102007	ENSG00000012660
Uniprot IDs		Q04941	A0A0A0MTI6 B3KWH9 Q9NYP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Water Transport Renal Water Transport One-carbon Compound Transport Urea Transmembrane Transport Urea Transport Fluid Transport PH-gated Chloride Channel Activity Mitochondrial Membrane Channel Activity Apical Plasma Membrane Ascorbate Homeostasis Steroid Dehydrogenase Activity Organic Hydroxy Compound Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Transmembrane Transport Urea Transmembrane Transporter Activity Identical Protein Binding Glycerol Transmembrane Transport Plasma Membrane Substrate Localization To Autophagosome Ammonium Channel Activity Polyol Transmembrane Transport	SNARE Complex SNAP Receptor Activity SNARE Binding Membrane Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Regulation Of Endothelial Cell Proliferation Membrane Fusion Mitochondrial Outer Membrane Large Intestinal Transit Negative Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Smooth Muscle Cell Proliferation Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Endomembrane System Vesicle Docking Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Vesicle Organization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Insulin-like Growth Factor Binding Protein Complex Membrane Docking Tertiary Granule Establishment Of Protein Localization Regulation Of Epithelial Cell Proliferation Cellular Response To Cisplatin Negative Regulation Of Locomotion Insulin-like Growth Factor Ternary Complex Membrane Destabilizing Activity Positive Regulation Of Receptor Localization To Synapse
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