VKORC1 and DPM2

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		VKORC1	DPM2
Description		vitamin K epoxide reductase complex subunit 1	dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity
	Biological Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Metabolism of vitamin K	Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases		Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)
Interacting Genes		93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24	7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1
Entrez ID		79001	8818
HPRD ID		10540	16028
Ensembl ID		ENSG00000167397	ENSG00000136908
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	O94777
PDB IDs		6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport	Glycolipid Biosynthetic Process Glycolipid Metabolic Process GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Protein O-linked Glycosylation Via Mannose Endoplasmic Reticulum Membrane Phosphatidylinositol Metabolic Process Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Glycerophospholipid Biosynthetic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum Glycerophospholipid Metabolic Process Carbohydrate Derivative Metabolic Process Glycerolipid Metabolic Process Organophosphate Metabolic Process MHC Class II Protein Complex Assembly Dolichyl-phosphate Beta-D-mannosyltransferase Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Lipid Metabolic Process Terpenoid Metabolic Process Pyrimidine Nucleoside Transmembrane Transporter Activity Amine Transmembrane Transporter Activity Isoprenoid Metabolic Process Alcohol Binding Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Protein O-linked Glycosylation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phosphate-containing Compound Metabolic Process Histamine Uptake Putrescine Transmembrane Transporter Activity Membrane Phosphatidylinositol N-acetylglucosaminyltransferase Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?