PLP2 and SPN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLP2	SPN
Description		proteolipid protein 2	sialophorin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Uropod Basement Membrane Extracellular Space Nucleus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding Monoatomic Ion Transmembrane Transporter Activity Chemokine Binding	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding
	Biological Process	Monoatomic Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Monoatomic Ion Transmembrane Transport	Response To Protozoan Negative Regulation Of Type IV Hypersensitivity T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Thymic T Cell Selection Regulation Of Defense Response To Virus Regulation Of Immune Response Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Leukocyte Tethering Or Rolling Apoptotic Signaling Pathway Regulation Of T Cell Migration Positive Regulation Of T Cell Migration
Pathways			Cell surface interactions at the vascular wall Basigin interactions
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494)
Interacting Genes		79 interacting genes: AQP2 AQP3 AQP6 AQP8 ARFIP2 ARL13B ASGR2 ATP5PF BCAP31 BIK BNIP3 CCR1 CD53 CD79A CERS4 CIAO2A CLDN5 CLN8 CPLX4 CRB3 CREB3L1 CYB561 CYBC1 CYBRD1 DARS2 DLGAP4 DNAJC1 EBP ELOVL5 ELP1 EVI2A FAM209A FAM210B FATE1 FCER1G FKBP7 FNDC9 GPR151 GPX8 HSBP1L1 HSD17B11 HSD17B13 KASH5 LHFPL1 LHFPL5 LMNA LRRC4C MGST3 MUC1 NDRG4 PACC1 PDZK1IP1 PIGP PSCA PTGES PVR REEP4 RETREG3 RNF5 SAR1A SCN3B SGPL1 SHBG SLC10A6 SLC14A2 SLC18A1 SLC2A13 SLC35H1 SPG21 SPN THAP4 TM4SF19 TMEM14B TMEM31 TMEM51 TMEM79 TMPRSS2 TMX2 VKORC1	18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2
Entrez ID		5355	6693
HPRD ID		02121	06770
Ensembl ID		ENSG00000102007	ENSG00000197471
Uniprot IDs		Q04941	P16150
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Water Transport Renal Water Transport One-carbon Compound Transport Urea Transmembrane Transport Urea Transport Fluid Transport PH-gated Chloride Channel Activity Mitochondrial Membrane Channel Activity Apical Plasma Membrane Ascorbate Homeostasis Steroid Dehydrogenase Activity Organic Hydroxy Compound Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Transmembrane Transport Urea Transmembrane Transporter Activity Identical Protein Binding Glycerol Transmembrane Transport Plasma Membrane Substrate Localization To Autophagosome Ammonium Channel Activity Polyol Transmembrane Transport	Membrane To Membrane Docking Disordered Domain Specific Binding Microvillus Membrane Cell Periphery Regulation Of Protein Catabolic Process Cell-cell Adhesion Establishment Of Endothelial Barrier T Cell Migration Endothelial Cell Development Lymphocyte Migration Leukocyte Cell-cell Adhesion Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Lymphocyte Activation Leukocyte Migration Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Protein Catabolic Process Uropod Apical Part Of Cell Membrane Docking Layer Formation In Cerebral Cortex Postsynaptic Density, Intracellular Component Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of ERAD Pathway Cell Adhesion Mononuclear Cell Migration Membrane Cell Migration Regulation Of Protein Localization T Cell Activation Leukocyte Activation Establishment Of Apical/basal Cell Polarity Negative Regulation Of Protein Catabolic Process Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of ERAD Pathway Epithelial Cell Development Plasma Membrane Regulation Of Cell Shape Positive Regulation Of Intracellular Transport Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell Activation Cell Motility Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
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