VKORC1 and APOA1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		VKORC1	APOA1
Description		vitamin K epoxide reductase complex subunit 1	apolipoprotein A1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding	Amyloid-beta Binding Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemorepellent Activity Receptor Ligand Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity
	Biological Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development	Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Involved In Immune Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Steroid Metabolic Process Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Amyloid-beta Formation High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Vitamin Transport Positive Regulation Of Stress Fiber Assembly Acylglycerol Homeostasis Phospholipid Homeostasis Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux Cellular Response To Amyloid-beta
Pathways		Metabolism of vitamin K	Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Combined deficiency of vitamin K-dependent clotting factors (VKCFD)	Hypoalphalipoproteinemia Familial amyloidosis
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565 24097068) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Diastolic blood pressure ( 27841878) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 19060906 26582766 20686565 24097068 20864672) HDL cholesterol levels ( 28334899) Hearing function ( 25060954) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 27599772 23505323) Infantile hypertrophic pyloric stenosis ( 23989729) LDL cholesterol ( 20864672 24097068 18179892 20686565 19060911) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 32759990) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 28371326 28548082 26763881 32759990) Triglycerides ( 24097068 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193046 18193044 18193043) Very low density lipoprotein cholesterol levels ( 28548082)
Interacting Genes		93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24	38 interacting genes: ABCA1 ABCA13 AKT2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR HSP90AA1 JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TRIM15 TTR VKORC1 VWF
Entrez ID		79001	335
HPRD ID		10540	02517
Ensembl ID		ENSG00000167397	ENSG00000118137
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	A0A024R3E3 P02647
PDB IDs		6WV3 6WV4 6WV5 6WV6 6WV7 6WVH	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F 7KJR 7RSC 7RSE 8EQS
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport	High-density Lipoprotein Particle Regulation Of Lipid Transport Regulation Of Cholesterol Transport Lipid Transport Cholesterol Metabolic Process Sterol Metabolic Process Sterol Transport Steroid Metabolic Process Lipoprotein Metabolic Process Apolipoprotein A-I Binding Cholesterol Transport Positive Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Extracellular Space Positive Regulation Of Lipid Transport Regulation Of Cholesterol Efflux High-density Lipoprotein Particle Remodeling Extracellular Region Organic Hydroxy Compound Transport Cholesterol Efflux High-density Lipoprotein Particle Binding Alcohol Metabolic Process Lipid Metabolic Process Apolipoprotein Binding Reverse Cholesterol Transport Lipid Homeostasis Extracellular Exosome Very-low-density Lipoprotein Particle Small Molecule Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Transfer Activity Positive Regulation Of Cholesterol Efflux Phosphatidylcholine Binding Positive Regulation Of Transport Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Detection Of Molecule Of Bacterial Origin Regulation Of Lipid Storage Regulation Of Transport Low-density Lipoprotein Particle Glycerolipid Metabolic Process Lipopolysaccharide Transport Low-density Lipoprotein Particle Binding Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Organophosphate Ester Transport
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