VKORC1 and ARL6IP5

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	ARL6IP5
Gene Name		vitamin K epoxide reductase complex, subunit 1	ADP-ribosylation factor-like 6 interacting protein 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Molecular_function Protein C-terminus Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential L-glutamate Transport Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transport
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	7 interactors: ARL6 CCR5 CLN8 PRAF2 RNF185 SLC1A1 VKORC1
Entrez ID		79001	10550
HPRD ID		10540	09303
Ensembl ID		ENSG00000167397	ENSG00000144746
Uniprot IDs		Q9BQB6	O75915
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	L-glutamate Transport Dicarboxylic Acid Transport L-glutamate Import Amino Acid Import Amino Acid Transport Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Cysteine Transport Intermembrane Transport L-glutamate Uptake Involved In Synaptic Transmission Anion Transport D-aspartate Import Ion Transport Retina Development In Camera-type Eye Visual Perception Sensory Perception Of Light Stimulus Age-dependent Response To Oxidative Stress Vitamin K Metabolic Process Somatic Motor Neuron Differentiation Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Aspartate Transport Sarcoplasmic Reticulum Calcium Ion Transport Neurotransmitter Uptake Protein Localization To Cilium Peptidyl-glutamic Acid Carboxylation Dendritic Cell Chemotaxis Neurofilament Cytoskeleton Organization Camera-type Eye Development Neuromuscular Process Controlling Posture Eye Development L-glutamate Transmembrane Transport Transport Response To Cholesterol Dendritic Cell Migration Retina Layer Formation Photoreceptor Cell Maintenance Melanosome Transport Release Of Sequestered Calcium Ion Into Cytosol Pigment Granule Transport Establishment Of Melanosome Localization Quinone Metabolic Process Drug Metabolic Process Regulation Of Sequestering Of Calcium Ion Sensory Organ Development Social Behavior Intermediate Filament Cytoskeleton Organization Melanosome Localization Entry Into Host Cell Intermediate Filament-based Process
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	abundantly acceptor adp belongs calmodulin ccaat chop delta2 enhances exocytic expresses histomorphometric hormones insufficiency knock knocked mineral osteoblast osteoblastic osteoblasts osteoclast osteoclastogenesis precursors prenylated rab rankl resorption ribosylation trabecular
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	abundantly acceptor adp belongs calmodulin ccaat chop delta2 enhances exocytic expresses histomorphometric hormones insufficiency knock knocked mineral osteoblast osteoblastic osteoblasts osteoclast osteoclastogenesis precursors prenylated rab rankl resorption ribosylation trabecular
Tagcloud (Intersection) ?