PLP2 and CERS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLP2	CERS4
Description		proteolipid protein 2	ceramide synthase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Monoatomic Ion Transmembrane Transporter Activity Chemokine Binding	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Monoatomic Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Monoatomic Ion Transmembrane Transport	Lipid Metabolic Process Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494)	Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		79 interacting genes: AQP2 AQP3 AQP6 AQP8 ARFIP2 ARL13B ASGR2 ATP5PF BCAP31 BIK BNIP3 CCR1 CD53 CD79A CERS4 CIAO2A CLDN5 CLN8 CPLX4 CRB3 CREB3L1 CYB561 CYBC1 CYBRD1 DARS2 DLGAP4 DNAJC1 EBP ELOVL5 ELP1 EVI2A FAM209A FAM210B FATE1 FCER1G FKBP7 FNDC9 GPR151 GPX8 HSBP1L1 HSD17B11 HSD17B13 KASH5 LHFPL1 LHFPL5 LMNA LRRC4C MGST3 MUC1 NDRG4 PACC1 PDZK1IP1 PIGP PSCA PTGES PVR REEP4 RETREG3 RNF5 SAR1A SCN3B SGPL1 SHBG SLC10A6 SLC14A2 SLC18A1 SLC2A13 SLC35H1 SPG21 SPN THAP4 TM4SF19 TMEM14B TMEM31 TMEM51 TMEM79 TMPRSS2 TMX2 VKORC1	47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2
Entrez ID		5355	79603
HPRD ID		02121	13962
Ensembl ID		ENSG00000102007	ENSG00000090661
Uniprot IDs		Q04941	Q53HF9 Q9HA82
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Water Transport Renal Water Transport One-carbon Compound Transport Urea Transmembrane Transport Urea Transport Fluid Transport PH-gated Chloride Channel Activity Mitochondrial Membrane Channel Activity Apical Plasma Membrane Ascorbate Homeostasis Steroid Dehydrogenase Activity Organic Hydroxy Compound Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Transmembrane Transport Urea Transmembrane Transporter Activity Identical Protein Binding Glycerol Transmembrane Transport Plasma Membrane Substrate Localization To Autophagosome Ammonium Channel Activity Polyol Transmembrane Transport	Membrane Amyloid Fibril Formation Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Exocytosis SNAP Receptor Activity Chloride Channel Inhibitor Activity Membrane Organization Positive Regulation Of Regulated Secretory Pathway SNARE Complex Syntaxin Binding Regulation Of Regulated Secretory Pathway Regulation Of Cellular Localization Regulation Of Protein Localization SNARE Binding
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