PLP2 and CLN8

Number of citations of the paper that reports this interaction (PMID 23142642)
0

Data Source:
BioGRID (two hybrid)

		PLP2	CLN8
Gene Name		proteolipid protein 2 (colonic epithelium-enriched)	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Ion Transmembrane Transporter Activity Chemokine Binding
	Biological Process	Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Ion Transmembrane Transport	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Negative Regulation Of Transferase Activity L-glutamate Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS			Gaucher disease severity ( 22388998)
Protein-Protein Interactions		9 interactors: BCAP31 CCDC155 CCR1 CLN8 DLGAP4 IKBKAP SHBG TMEM79 VKORC1	29 interactors: ARL6IP5 BNIP3 BNIP3L C14orf1 CD9 CYB5B GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUFSP
Entrez ID		5355	2055
HPRD ID		02121	06383
Ensembl ID		ENSG00000102007	ENSG00000182372
Uniprot IDs		Q04941	Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Localization To Nuclear Envelope Involved In Synapsis Primary Spermatocyte Growth Spermatogenesis Male Gamete Generation L-glutamate Uptake Involved In Synaptic Transmission Homeostatic Process Cuticle Development Gamete Generation Cornification Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Age-dependent Response To Oxidative Stress Protein Localization To Endoplasmic Reticulum Exit Site Vitamin K Metabolic Process Sexual Reproduction Multicellular Organismal Reproductive Process Somatic Motor Neuron Differentiation Multicellular Organism Reproduction L-glutamate Import Chemical Homeostasis Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Monocyte Chemotaxis Establishment Of Localization In Cell Neurotransmitter Uptake Calcium-mediated Signaling Using Intracellular Calcium Source Peptidyl-glutamic Acid Carboxylation Cellular Calcium Ion Homeostasis Regulation Of Monocyte Chemotaxis Dendritic Cell Chemotaxis Neurofilament Cytoskeleton Organization Reproduction Calcium Ion Homeostasis Neuromuscular Process Controlling Posture Amino Acid Import Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Mitochondrial Calcium Ion Homeostasis Establishment Of Skin Barrier Exocytosis Positive Regulation Of Cellular Component Movement	Mitochondrial Protein Catabolic Process Transport Membrane Organization Apoptotic Signaling Pathway Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Establishment Of Localization In Cell Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Membrane Fusion Apoptotic Process Cellular Localization Programmed Cell Death Cell Death Death Mitochondrial Transport Organelle Organization Intracellular Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Oligodendrocyte Development Substantia Nigra Development Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Neural Nucleus Development Gliogenesis Mitochondrial Membrane Organization Protein Transport Dense Core Granule Maturation Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Process Oligodendrocyte Differentiation Establishment Of Protein Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Stress Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Serotonin Uptake Midbrain Development Glial Cell Development Cellular Response To Hypoxia Cell Communication Cellular Response To Decreased Oxygen Levels Negative Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway
Tagcloud ?		antiviral bona coronavirus coronaviruses deubiquitinates engages ensure escape fide hcov ifnbeta immunopathology innate interferon irf7 mdm2 meanwhile nl63 nonstructural oncoprotein papain plps proteases proteasomal rampant reveals stabilizes suppressors usually	brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Difference) ?		antiviral bona coronavirus coronaviruses deubiquitinates engages ensure escape fide hcov ifnbeta immunopathology innate interferon irf7 mdm2 meanwhile nl63 nonstructural oncoprotein papain plps proteases proteasomal rampant reveals stabilizes suppressors usually	brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Intersection) ?