VKORC1 and BCAP31

Number of citations of the paper that reports this interaction (PubMedID 21103663)
0

Data Source:
BioGRID (two hybrid)

		VKORC1	BCAP31
Description		vitamin K epoxide reductase complex subunit 1	B cell receptor associated protein 31
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Clathrin-coated Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Perinuclear Endoplasmic Reticulum Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding	Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding
	Biological Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development	Protein Targeting To Mitochondrion Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Spermatogenesis Protein Transport Vesicle-mediated Transport Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Exit Site Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Positive Regulation Of ERAD Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Metabolism of vitamin K	Apoptotic cleavage of cellular proteins Apoptotic execution phase RHOA GTPase cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC RSV-host interactions
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases		Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24	30 interacting genes: ACTG1 APP AQP2 BCAP29 BCL2 BCL2L1 CANX CASP1 CASP3 CASP8 CDC42 CEBPA DRD2 FIS1 GPRIN2 HACD2 HLA-A IGHD KLK10 MSN MYH10 PLP2 SERPINF2 TIMMDC1 TMEM31 VAMP1 VAMP2 VAMP3 VKORC1 YWHAQ
Entrez ID		79001	10134
HPRD ID		10540	02319
Ensembl ID		ENSG00000167397	ENSG00000185825
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	P51572
PDB IDs		6WV3 6WV4 6WV5 6WV6 6WV7 6WVH	4JZL 4JZP 8XWX
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport	Response To Peptide Response To Cytokine Regulation Of Transport SNARE Complex Assembly Response To Metal Ion Cell Projection Morphogenesis Positive Regulation Of Gene Expression Axonogenesis Neuron Projection Morphogenesis Cellular Response To Type II Interferon Membrane Positive Regulation Of Interleukin-1 Production Regulation Of Defense Response Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Inflammatory Response Regulation Of Body Fluid Levels Dendritic Cell Apoptotic Process Positive Regulation Of Inflammatory Response Membrane Organization Cellular Component Assembly Vesicle-mediated Transport Neuron Projection Positive Regulation Of Cytokine Production Response To Type II Interferon Mitochondrial Outer Membrane Regulation Of Vesicle-mediated Transport Protein-containing Complex SNAP Receptor Activity Regulation Of Immune System Process BH3 Domain Binding Response To Anesthetic Channel Activity Regulation Of Interleukin-1 Production Renal System Process Blood Microparticle Regulation Of Cytokine Production Response To Nicotine Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Histamine Secretion By Mast Cell Defense Response Cell Surface Receptor Signaling Pathway Macrophage Differentiation SNARE Complex Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Synaptic Vesicle Membrane Endocytosis Negative Regulation Of Dendritic Cell Apoptotic Process
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