VKORC1 and APOC3

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	APOC3
Gene Name		vitamin K epoxide reductase complex, subunit 1	apolipoprotein C-III
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Phospholipid Binding Cholesterol Binding Enzyme Regulator Activity Lipase Inhibitor Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Retinoid Metabolic Process Triglyceride Metabolic Process Triglyceride Mobilization Inflammatory Response G-protein Coupled Receptor Signaling Pathway Response To Nutrient Phototransduction, Visible Light Cholesterol Metabolic Process Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Triglyceride Catabolic Process Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Lipoprotein Transport Response To Peptide Hormone Reverse Cholesterol Transport Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Cholesterol Import Triglyceride Homeostasis Cellular Response To Glucose Stimulus
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Lipoprotein metabolism HDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)	Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) HDL cholesterol ( 20864672 19060906 20686565) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	3 interactors: ARFGAP1 UBC VKORC1
Entrez ID		79001	345
HPRD ID		10540	00132
Ensembl ID		ENSG00000167397	ENSG00000110245
Uniprot IDs		Q9BQB6	A3KPE2 P02656
PDB IDs			2JQ3
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Vitamin K Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Viral Protein Processing COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Transferase Activity Golgi Vesicle Budding Positive Regulation Of Protein Phosphorylation Notch Receptor Processing Regulation Of Protein Kinase Activity Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Kinase Activity Glycogen Biosynthetic Process Intracellular Transport Of Virus Vesicle Targeting, To, From Or Within Golgi Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Retrograde Vesicle-mediated Transport, Golgi To ER Quinone Metabolic Process Drug Metabolic Process Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Localization Within Membrane Vesicle Targeting Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of ERBB Signaling Pathway Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Nuclease Activity Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	19x allele amish architecture atherosclerotic cardio conferring epidemiology ethnic ethnicity founder genomics genotyped geometric indiana lipoprotein means nhanes noncarrier nutrition ohio pennsylvania r19x racial rs76353203 subclinical surveys triglyceride triglycerides
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	19x allele amish architecture atherosclerotic cardio conferring epidemiology ethnic ethnicity founder genomics genotyped geometric indiana lipoprotein means nhanes noncarrier nutrition ohio pennsylvania r19x racial rs76353203 subclinical surveys triglyceride triglycerides
Tagcloud (Intersection) ?