VKORC1 and PCDH1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	PCDH1
Gene Name		vitamin K epoxide reductase complex, subunit 1	protocadherin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Calcium Ion Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Signaling Nervous System Development
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)	Major depressive disorder ( 23377640) Myopia (pathological) ( 23406873)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	3 interactors: ATF7IP SMAD3 VKORC1
Entrez ID		79001	5097
HPRD ID		10540	04692
Ensembl ID		ENSG00000167397	ENSG00000156453
Uniprot IDs		Q9BQB6	A8K0E7 B4DUA8 B4E2D8 Q08174
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Gene Expression, Epigenetic Evasion Or Tolerance Of Host Defenses By Virus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Extracellular Matrix Assembly Primary MiRNA Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Vitamin K Metabolic Process Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Transdifferentiation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Alkaline Phosphatase Activity Paraxial Mesoderm Morphogenesis Viral Process Skeletal System Development Peptidyl-glutamic Acid Carboxylation Wound Healing Nodal Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Osteoblast Proliferation Response To Wounding Embryonic Foregut Morphogenesis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Production Of MiRNAs Involved In Gene Silencing By MiRNA Foregut Morphogenesis Regulation Of DNA-templated Transcription, Initiation Modulation By Virus Of Host Morphology Or Physiology Paraxial Mesoderm Development Regulation Of Catenin Import Into Nucleus Thyroid Gland Development Osteoblast Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Chondrocyte Differentiation Pericardium Development Positive Regulation Of Phosphatase Activity Positive Regulation Of Positive Chemotaxis Positive Regulation Of Interleukin-1 Production Signal Transduction Involved In Regulation Of Gene Expression Activin Receptor Signaling Pathway Lens Fiber Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Gene Silencing By MiRNA Positive Regulation Of Bone Mineralization Cellular Response To DsRNA
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	ahnak apparatus biobalistic colocalized cottontail crpv desmoyokin disturbing e5 e7 e8 endosomes hpv16 hpvs inoculation interacted keratinocytes nonfunctional oncogenes oncoprotein papilloma player protocadherin pvs rabbit scarce unravel wart znt1
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	ahnak apparatus biobalistic colocalized cottontail crpv desmoyokin disturbing e5 e7 e8 endosomes hpv16 hpvs inoculation interacted keratinocytes nonfunctional oncogenes oncoprotein papilloma player protocadherin pvs rabbit scarce unravel wart znt1
Tagcloud (Intersection) ?