VKORC1 and FGL1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	FGL1
Gene Name		vitamin K epoxide reductase complex, subunit 1	fibrinogen-like 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Fibrinogen Complex Extracellular Vesicular Exosome
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Cholesterol Metabolic Process Regulation Of Glucose Metabolic Process Response To Stilbenoid Adipose Tissue Development
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	2 interactors: BCL2L11 VKORC1
Entrez ID		79001	2267
HPRD ID		10540	09312
Ensembl ID		ENSG00000167397	ENSG00000104760
Uniprot IDs		Q9BQB6	Q08830
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process By Virus Positive Regulation Of Fibroblast Apoptotic Process B Cell Apoptotic Process Vitamin K Metabolic Process Post-embryonic Organ Morphogenesis Thymocyte Apoptotic Process Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Cellular Process Regulating Host Cell Cycle In Response To Virus Positive Regulation Of Protein Homooligomerization Modulation By Virus Of Host Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Peptidyl-glutamic Acid Carboxylation Cellular Response To Virus T Cell Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Protein Oligomerization Modulation By Virus Of Host Morphology Or Physiology Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Developmental Pigmentation Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Morphogenesis Killing Of Cells Of Other Organism Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Process Involved In Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Oligomerization Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Membrane Permeability B Cell Homeostasis T Cell Homeostasis Quinone Metabolic Process Drug Metabolic Process Developmental Programmed Cell Death Spleen Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Thymus Development Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Mitochondrial Membrane Organization Developmental Pigmentation Lymphocyte Homeostasis Apoptotic Mitochondrial Changes Embryonic Digit Morphogenesis Positive Regulation Of Neuron Death Cellular Ketone Metabolic Process
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	adipocytes annexin attenuates bl6 bm c57 ccl4 cd44 cd54 cd73 cd90 chondrocytes ck18 cm conditioned cytokeratin hepatocyte hepatocytes hnf4 injecting intraperitoneally microparticles mps msc mscs osteocytes plating tetrachloride transcriptase
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	adipocytes annexin attenuates bl6 bm c57 ccl4 cd44 cd54 cd73 cd90 chondrocytes ck18 cm conditioned cytokeratin hepatocyte hepatocytes hnf4 injecting intraperitoneally microparticles mps msc mscs osteocytes plating tetrachloride transcriptase
Tagcloud (Intersection) ?