PLP1 and CANX

Number of citations of the paper that reports this interaction (PMID 12805210)
18

Data Source:
HPRD (in vitro, in vivo)

		PLP1	CANX
Gene Name		proteolipid protein 1	calnexin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Myelin Sheath	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Structural Molecule Activity Structural Constituent Of Myelin Sheath	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Inflammatory Response Integrin-mediated Signaling Pathway Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Long-chain Fatty Acid Biosynthetic Process Cell Maturation Axon Development	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis
Pathways			Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs			Antihemophilic Factor Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CALR CANX CLN8 ITGAV MAG MBP PTPRN	42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR
Entrez ID		5354	821
HPRD ID		02321	00252
Ensembl ID		ENSG00000123560	ENSG00000127022
Uniprot IDs		A8K9L3 B4DI30 P60201	P27824
PDB IDs		2XPG
Enriched GO Terms of Interacting Partners?		Aging Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Negative Regulation Of Neuron Differentiation Generation Of Neurons Negative Regulation Of Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Neurogenesis Substantia Nigra Development Response To Stress Antigen Processing And Presentation Negative Regulation Of Neurogenesis Positive Regulation Of Phagocytosis Negative Regulation Of Cell Development Neural Nucleus Development Immune System Process Chaperone-mediated Protein Folding Negative Regulation Of Axonogenesis Nervous System Development Regulation Of Phagocytosis Regulation Of Cell Morphogenesis Response To Steroid Hormone Midbrain Development Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Protein N-linked Glycosylation Via Asparagine Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Neuron Projection Development Protein N-linked Glycosylation Protein Secretion Regulation Of Cell Differentiation Regulation Of Entry Of Bacterium Into Host Cell Dense Core Granule Maturation L-glutamate Uptake Involved In Synaptic Transmission Endocytosis Negative Regulation Of Cell Projection Organization Regulation Of Neurogenesis Defense Response To Nematode Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Developmental Process Regulation Of Axonogenesis Cell Differentiation Signaling Cell Communication Sequestering Of Calcium Ion Regulation Of Cellular Component Organization	Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization
Tagcloud ?		bace1 bingo cdk2 clustering criterion cytoscape degs downloaded elavl1 glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plug software string webgestalt wee1	5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Difference) ?		bace1 bingo cdk2 clustering criterion cytoscape degs downloaded elavl1 glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plug software string webgestalt wee1	5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Intersection) ?