PLP1 and PI16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLP1	PI16
Description		proteolipid protein 1	peptidase inhibitor 16
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Myelin Sheath Synapse	Extracellular Region Extracellular Space
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding	Protein Binding Peptidase Inhibitor Activity
	Biological Process	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development	Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Pathways
Drugs
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS			Acne (severe) ( 24927181) Atrial fibrillation ( 30061737) Chemerin levels ( 20237162) Diverticular disease ( 30177863) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Interacting Genes		91 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYB5R3 CYBC1 DCT DYRK1A DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FKBP7 FNDC9 GAST GJA8 GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC35H1 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1	6 interacting genes: ATP6V0C PLP1 STRIT1 TMBIM6 TMEM60 TMEM86A
Entrez ID		5354	221476
HPRD ID		02321	11430
Ensembl ID		ENSG00000123560	ENSG00000164530
Uniprot IDs		A0A0S2Z4D4 A8K9L3 B4DI30 P60201	Q6UXB8
PDB IDs		2XPG
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Negative Regulation Of Apoptotic Signaling Pathway Compact Myelin Antiporter Activity	Endoribonuclease Inhibitor Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Alkenylglycerophosphocholine Hydrolase Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction
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