PLP1 and MBP

Number of citations of the paper that reports this interaction (PMID 2467009)
4

Data Source:
HPRD (in vitro)

		PLP1	MBP
Gene Name		proteolipid protein 1	myelin basic protein
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Myelin Sheath	Nucleus Plasma Membrane Internode Region Of Axon Neuronal Cell Body Compact Myelin
	Molecular Function	Structural Molecule Activity Structural Constituent Of Myelin Sheath	Protease Binding Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Inflammatory Response Integrin-mediated Signaling Pathway Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Long-chain Fatty Acid Biosynthetic Process Cell Maturation Axon Development	Immune Response Synaptic Transmission Central Nervous System Development Aging Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Response To Progesterone Response To Tumor Necrosis Factor Myelination Response To Mercury Ion Negative Regulation Of Axonogenesis Membrane Organization Response To Fatty Acid
Pathways
Drugs
Diseases
GWAS			Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		7 interactors: CALR CANX CLN8 ITGAV MAG MBP PTPRN	72 interactors: ABL1 APTX ATN1 ATXN1 BMP2K CCNC CCNH CCNT1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 DYRK1B HIPK2 HLA-DRA IKBKE IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPKAPK5 MELK MICU2 MKNK1 MMP7 MNAT1 NEK9 PAK1 PKN1 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1
Entrez ID		5354	4155
HPRD ID		02321	01158
Ensembl ID		ENSG00000123560	ENSG00000197971
Uniprot IDs		A8K9L3 B4DI30 P60201	P02686
PDB IDs		2XPG	1BX2 1FV1 1HQR 1QCL 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Aging Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Negative Regulation Of Neuron Differentiation Generation Of Neurons Negative Regulation Of Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Neurogenesis Substantia Nigra Development Response To Stress Antigen Processing And Presentation Negative Regulation Of Neurogenesis Positive Regulation Of Phagocytosis Negative Regulation Of Cell Development Neural Nucleus Development Immune System Process Chaperone-mediated Protein Folding Negative Regulation Of Axonogenesis Nervous System Development Regulation Of Phagocytosis Regulation Of Cell Morphogenesis Response To Steroid Hormone Midbrain Development Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Protein N-linked Glycosylation Via Asparagine Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Neuron Projection Development Protein N-linked Glycosylation Protein Secretion Regulation Of Cell Differentiation Regulation Of Entry Of Bacterium Into Host Cell Dense Core Granule Maturation L-glutamate Uptake Involved In Synaptic Transmission Endocytosis Negative Regulation Of Cell Projection Organization Regulation Of Neurogenesis Defense Response To Nematode Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Developmental Process Regulation Of Axonogenesis Cell Differentiation Signaling Cell Communication Sequestering Of Calcium Ion Regulation Of Cellular Component Organization	Protein Phosphorylation Phosphorylation Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Signal Transduction By Phosphorylation Protein Autophosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Protein Kinase Activity Peptidyl-threonine Phosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway MAPK Cascade Cellular Response To Stress Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Stimulus Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Death Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Metabolic Process Response To Stimulus Regulation Of MAP Kinase Activity Apoptotic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process
Tagcloud ?		bace1 bingo cdk2 clustering criterion cytoscape degs downloaded elavl1 glioma gse31262 hierarchical kif23 kobas language limma log2fc mbp multtest myelination omnibus ontology package pheatmap plug software string webgestalt wee1	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Difference) ?		bace1 bingo cdk2 clustering criterion cytoscape degs downloaded elavl1 glioma gse31262 hierarchical kif23 kobas language limma log2fc multtest myelination omnibus ontology package pheatmap plug software string webgestalt wee1	ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mst1 mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad
Tagcloud (Intersection) ?		mbp