PLP1 and CYBC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLP1	CYBC1
Description		proteolipid protein 1	cytochrome b-245 chaperone 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Myelin Sheath Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding	Protein Binding
	Biological Process	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development	Immune System Process Innate Immune Response Respiratory Burst After Phagocytosis
Pathways
Drugs
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS
Interacting Genes		91 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYB5R3 CYBC1 DCT DYRK1A DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FKBP7 FNDC9 GAST GJA8 GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC35H1 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1	65 interacting genes: ADIPOQ AGTRAP AHNAK2 AIG1 APCDD1L APOA2 APOL2 AQP10 AQP6 AQP8 ARLN BET1 C14orf180 CD53 CISD2 CLDN7 CLN6 COQ9 CPLX4 CREB3 CREB3L1 CYBB ERGIC3 ETS1 FAM209A GJA8 GPR151 GPR152 GPX8 HSD17B11 HSD17B13 INSIG2 JAGN1 KASH5 KIR2DL3 LAT LMNA LXN MFF MGST3 MTIF3 NINJ2 NOX3 NRM P2RX1 PDZK1IP1 PEX12 PLIN3 PLP1 PLP2 SCD SHISA4 SLC35H1 SLC71A2 SPN SSMEM1 STX2 THBD TM4SF19 TMEM128 TMEM80 TMPRSS2 TMX2 TRAM1L1 TSPAN12
Entrez ID		5354	79415
HPRD ID		02321	14630
Ensembl ID		ENSG00000123560	ENSG00000178927
Uniprot IDs		A0A0S2Z4D4 A8K9L3 B4DI30 P60201	Q9BQA9
PDB IDs		2XPG	8KEI
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Negative Regulation Of Apoptotic Signaling Pathway Compact Myelin Antiporter Activity	Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Water Channel Activity Channel Activity Negative Regulation Of Cholesterol Import Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Regulation Of Cholesterol Import One-carbon Compound Transport Water Transport Superoxide-generating NADPH Oxidase Activity Identical Protein Binding Fluid Transport Lipid Droplet Ammonium Channel Activity Urea Transmembrane Transport
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