PLP1 and TMEM52B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLP1	TMEM52B
Description		proteolipid protein 1	transmembrane protein 52B
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Myelin Sheath Synapse	Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding	Protein Binding
	Biological Process	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development
Pathways
Drugs
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS
Interacting Genes		91 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYB5R3 CYBC1 DCT DYRK1A DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FKBP7 FNDC9 GAST GJA8 GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC35H1 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1	70 interacting genes: ALG3 APOD APOL2 APOL3 BET1 BTN2A2 C1GALT1 C3orf52 CLDN19 CLDN4 CNIH1 CNIH3 CRYAA CSGALNACT2 DNAJC30 EMD FXYD3 GAST GPR25 GPR37L1 IGFBP5 INSIG2 ITGAM JAGN1 LHFPL5 LPAR3 LTC4S MAL MARCHF2 MIP MS4A13 NINJ2 NRM NSG1 ORMDL1 PEDS1-UBE2V1 PGAP2 PLN PLP1 RTP2 SEC22A SERP1 SLC30A2 SLC30A8 SLC35A4 SLC35B4 SLC38A7 SMIM1 TF TMEM100 TMEM107 TMEM109 TMEM128 TMEM147 TMEM14C TMEM203 TMEM218 TMEM267 TMEM50B TMEM54 TMEM60 TMEM86B TMEM97 TMUB2 TRAM1L1 TRARG1 VAMP3 VAMP5 YIPF6 ZDHHC15
Entrez ID		5354	120939
HPRD ID		02321	08709
Ensembl ID		ENSG00000123560	ENSG00000165685
Uniprot IDs		A0A0S2Z4D4 A8K9L3 B4DI30 P60201	Q4KMG9
PDB IDs		2XPG
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Negative Regulation Of Apoptotic Signaling Pathway Compact Myelin Antiporter Activity	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Membrane Protein Binding Golgi Membrane Localization Within Membrane Establishment Of Protein Localization To Plasma Membrane Cellular Localization Protein Insertion Into Membrane Establishment Of Protein Localization Zinc:proton Antiporter Activity Nuclear Outer Membrane Protein Localization To Membrane Paracellular Transport Protein Localization To Postsynapse Lipid Binding SNAP Receptor Activity Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Import Into Organelle Intestinal Epithelial Cell Development Pyrimidine Nucleotide-sugar Transmembrane Transport Vesicle-mediated Transport
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