PLP1 and TMPRSS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLP1	TMPRSS2
Description		proteolipid protein 1	transmembrane serine protease 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Myelin Sheath Synapse	Extracellular Region Nucleoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development	Proteolysis Protein Autoprocessing Viral Translation Positive Regulation Of Viral Entry Into Host Cell Entry Receptor-mediated Virion Attachment To Host Cell
Pathways			Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion
Drugs			Bromhexine Camostat MM3122
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)	Prostate cancer
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		91 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYB5R3 CYBC1 DCT DYRK1A DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FKBP7 FNDC9 GAST GJA8 GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC35H1 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1	60 interacting genes: ACE2 ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF UPK2 VAMP5 ZFPL1
Entrez ID		5354	7113
HPRD ID		02321	03637
Ensembl ID		ENSG00000123560	ENSG00000184012
Uniprot IDs		A0A0S2Z4D4 A8K9L3 B4DI30 P60201	A0A7I2V474 O15393
PDB IDs		2XPG	7MEQ 7XYD 7Y0E 7Y0F 8HD8 8JHZ 8JI0 8S0L 8S0M 8S0N 8V04 8V1F 8VGT 8Y1D 8Y1E 8Y7X 8Y7Y 8Y87 8Y88 8Y89 8Y8A 8Y8B 8YOY 8YQQ 9IZN
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Negative Regulation Of Apoptotic Signaling Pathway Compact Myelin Antiporter Activity	Membrane Endoplasmic Reticulum Membrane Protein Binding Positive Regulation Of Monocyte Chemotactic Protein-1 Production Alkenylglycerophosphocholine Hydrolase Activity Endoplasmic Reticulum Respiratory Burst After Phagocytosis Response To Bacterium Cytokine Activity Positive Regulation Of Chemokine Production CCR6 Chemokine Receptor Binding Killing By Host Of Symbiont Cells Chloride Channel Inhibitor Activity SNAP Receptor Activity Biological Process Involved In Interaction With Symbiont Identical Protein Binding Regulation Of Chemokine Production Respiratory Burst Involved In Defense Response
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