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PLCG1 and PAK1
Number of citations of the paper that reports this interaction (PubMedID
12085993
)
0
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, in vitro)
PLCG1
PAK1
Description
phospholipase C gamma 1
p21 (RAC1) activated kinase 1
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
COP9 Signalosome
Lamellipodium
Ruffle Membrane
Cell Projection
Ruffle
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Membrane
Z Disc
Lamellipodium
Axon
Dendrite
Nuclear Membrane
Ruffle Membrane
Protein-containing Complex
Cell Projection
Anchoring Junction
Molecular Function
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Phospholipase C Activity
Guanyl-nucleotide Exchange Factor Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Phosphoric Diester Hydrolase Activity
Hydrolase Activity
Protein Kinase Binding
Metal Ion Binding
Calcium-dependent Phospholipase C Activity
Phosphatidylinositol Phospholipase C Activity
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Small GTPase Binding
Identical Protein Binding
Gamma-tubulin Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Lipid Metabolic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Lipid Catabolic Process
Cell Migration
Calcium-mediated Signaling
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Phosphatidylinositol-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Sequestering Of Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
MAPK Cascade
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Chromatin Remodeling
Exocytosis
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Positive Regulation Of Fibroblast Migration
Cell Migration
Cerebellum Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Microtubule Polymerization
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Regulation Of MAPK Cascade
Positive Regulation Of Axon Extension
Positive Regulation Of Insulin Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of Microtubule Nucleation
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Actin Filament Organization
Protein Localization To Cytoplasmic Stress Granule
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Signaling by ALK
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by ALK fusions and activated point mutants
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Drugs
Fostamatinib
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Tourette syndrome (
30818990
)
Interacting Genes
112 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RBM11
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
89 interacting genes:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BCL6
BMPR1B
BMX
BRSK1
BTG3
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CPLANE1
CSNK2A1
CSNK2A2
DSCAM
DSCR9
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
H3C1
H4C1
HACE1
HGS
HSP90AA1
KEAP1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1A
PPM1F
PPP1CA
PPP2CA
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
Entrez ID
5335
5058
HPRD ID
01398
03995
Ensembl ID
ENSG00000124181
ENSG00000149269
Uniprot IDs
P19174
B3KNX7
E9PM17
Q13153
PDB IDs
1HSQ
2HSP
4EY0
4FBN
7NXE
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
6B16
7VTO
8X5Z
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Activity
Plasma Membrane
Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Phosphorylation
Regulation Of Signal Transduction
Protein Autophosphorylation
Positive Regulation Of Signal Transduction
Cell Migration
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Receptor Complex
Antigen Receptor-mediated Signaling Pathway
Cell Motility
Activation Of Immune Response
Immune System Process
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Population Proliferation
Fc Receptor Signaling Pathway
ATP Binding
Cell Activation
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Population Proliferation
Response To Growth Factor
Developmental Process
Nucleotide Binding
Leukocyte Activation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Protein Kinase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Signal Transduction
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Developmental Process
Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Regulation Of Signal Transduction
Anatomical Structure Morphogenesis
Regulation Of Supramolecular Fiber Organization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Component Organization
Protein Phosphorylation
ERBB Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Locomotion
Focal Adhesion
Regulation Of Cell Differentiation
Regulation Of Intracellular Signal Transduction
Lamellipodium
Phosphorylation
Regulation Of Anatomical Structure Morphogenesis
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Motility
Protein Kinase Binding
Regulation Of Locomotion
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Motility
Positive Regulation Of Cell Migration
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cytoskeleton Organization
Regulation Of Cell Migration
Developmental Process
Regulation Of Cytoskeleton Organization
Positive Regulation Of Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Adhesion
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Protein Localization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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